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JNJ 28871063

a pan-erbB kinase inhibitor; structure in first source

Also Known As:

JNJ-28871063; JNJ28871063

Networked: 1 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - JNJ 28871063: 1
  - Oxazines: 9
    - Morpholines: 6
      - JNJ 28871063: 1

Experts

1.	Adams, Mary: 1 article (02/2008)
2.	Borowski, Virna: 1 article (02/2008)
3.	Butler, Jeannene: 1 article (02/2008)
4.	Connolly, Peter J: 1 article (02/2008)
5.	Emanuel, Stuart L: 1 article (02/2008)
6.	Fuentes-Pesquera, Angel: 1 article (02/2008)
7.	Greenberger, Lee M: 1 article (02/2008)
8.	Gruninger, Robert H: 1 article (02/2008)
9.	Hollister, Beth: 1 article (02/2008)
10.	Hughes, Terry V: 1 article (02/2008)

Related Diseases

1.

Neoplasms (Cancer)

02/01/2008 - "Tissue distribution studies show that JNJ-28871063 crosses the blood-brain barrier and penetrates into tumors, where it is able to accumulate to higher levels than those found in the plasma. "
02/01/2008 - "These results show that JNJ-28871063 is orally bioavailable, has activity against EGFR and ErbB2-dependent tumor xenografts, and can penetrate into the brain and inhibit ErbB2-overexpressing tumor growth."
02/01/2008 - "In an intracranial ErbB2-overexpressing tumor model, JNJ-28871063 extended survival relative to untreated animals. "
02/01/2008 - "JNJ-28871063 showed oral antitumor activity in human tumor xenograft models that overexpress EGFR and ErbB2. "
02/01/2008 - "Cellular and in vivo activity of JNJ-28871063, a nonquinazoline pan-ErbB kinase inhibitor that crosses the blood-brain barrier and displays efficacy against intracranial tumors."

Related Drugs and Biologics

1.	Phosphotransferases (Kinase)
2.	Tyrosine (L-Tyrosine)