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6- (4- hydroxyphenyl)- 2- thioxo- 2,3- dihydro- 4(1H)- pyrimidinone

inhibits the Mrer11-Rad50-Nbs1 complex; structure in first source

Also Known As:

mirin

Networked: 8 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - Pyrimidinones: 71
      - 6-(4-hydroxyphenyl)-2-thioxo-2,3-dihydro-4(1H)-pyrimidinone: 8
Inorganic Chemicals: 9
- Thiones: 70
  - 6-(4-hydroxyphenyl)-2-thioxo-2,3-dihydro-4(1H)-pyrimidinone: 8
Organic Chemicals: 133
- Sulfur Compounds: 278
  - Thiones: 70
    - 6-(4-hydroxyphenyl)-2-thioxo-2,3-dihydro-4(1H)-pyrimidinone: 8

Experts

1.	Jividen, Kasey: 1 article (10/2018)
2.	Kedzierska, Katarzyna Z: 1 article (10/2018)
3.	Paschal, Bryce M: 1 article (10/2018)
4.	Ratan, Aakrosh: 1 article (10/2018)
5.	Szlachta, Karol: 1 article (10/2018)
6.	Yang, Chun-Song: 1 article (10/2018)
7.	Bartolazzi, Armando: 1 article (01/2018)
8.	Belardinilli, Francesca: 1 article (01/2018)
9.	Capalbo, Carlo: 1 article (01/2018)
10.	Cardinali, Beatrice: 1 article (01/2018)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2018 - "Encapsulation of mirin in nanoparticles allowed its use on MYCN-amplified neuroblastoma xenografts in vivo, which resulted in a sharp impairment of tumor growth, associated with DDR activation, p53 accumulation, and cell death. " 09/01/2014 - "Mirin has successfully uncovered oncomirs and their regulatory networks in various cancers, such as gastric and breast cancer. " 09/01/2014 - "Mirin is a web-based application suitable for identifying functional modules from protein-protein interaction networks regulated by aberrant miRNAs under user-defined biological conditions such as cancers. " 01/01/2012 - "Researchers recently developed three ATM inhibitors (KU-55933, CGK733, and CP466722) and an MRN complex inhibitor (mirin) and showed that they have great potential as radiosensitizers of tumors in preclinical studies. "
2.	Ovarian Neoplasms (Ovarian Cancer) 06/30/2023 - "Here, we show that effecting an MRE11 blockade using a prototypical inhibitor (Mirin) induces synthetic lethality (SL) in BRCA2-deficient ovarian cancer cells, HeLa cells, and 3D spheroids compared to BRCA2-proficient controls. " 07/19/2022 - "Pre-clinically, Mre11 depletion by gene knock down or blockade by small molecule inhibitor (Mirin) reversed platinum resistance in ovarian cancer cells and in 3D spheroid models. "
3.	Prostatic Neoplasms (Prostate Cancer) 10/10/2018 - "We found that inhibition of the DNA repair enzyme MRE11 with the small molecule mirin inhibits androgen-dependent transcription and growth of prostate cancer cells. "
4.	Neuroblastoma 01/01/2018 - "Encapsulation of mirin in nanoparticles allowed its use on MYCN-amplified neuroblastoma xenografts in vivo, which resulted in a sharp impairment of tumor growth, associated with DDR activation, p53 accumulation, and cell death. "
5.	Hypersensitivity (Allergy) 06/01/2012 - "BRCA2-deficient cells also showed hypersensitivity to the Mre11 inhibitor mirin. "

Related Drugs and Biologics

1.	2- (6,7- dimethoxyquinazolin- 4- yl)- 5- (pyridiin- 2- yl)- 2H- 1,2,4- triazol- 3- amine
2.	CGK 733
3.	2- morpholin- 4- yl- 6- thianthren- 1- yl- pyran- 4- one
4.	DNA Repair Enzymes
5.	MicroRNAs (MicroRNA)
6.	Solutions
7.	Platinum
8.	Glucose (Dextrose)
9.	Enzymes
10.	Androgens

Related Therapies and Procedures

1.	Oral Administration