WB1106

an oxide-releasing derivative of telmisartan that inhibits hypertension and improves glucose metabolism in rats; structure in first source

Also Known As:

(6-(nitrooxymethyl)pyridin-2-yl)methyl 4'-(1-(1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzo(d)imidazol-3'-yl)ethyl)biphenyl-2-carboxylate

Networked: 1 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzimidazoles: 245
      - WB1106: 1
Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Benzoates: 426
        WB1106: 1
- Carboxylic Acids: 973
  - Carbocyclic Acids
    - Benzoates: 426
      - WB1106: 1

Experts

1.	Chen, Xiu-Ying: 1 article (12/2007)
2.	Du, Guan-Tao: 1 article (12/2007)
3.	Ji, Hui: 1 article (12/2007)
4.	Li, Yong-Qi: 1 article (12/2007)
5.	Meng, Zhao-Ke: 1 article (12/2007)
6.	Shi, Wei-Bing: 1 article (12/2007)
7.	Tian, Jide: 1 article (12/2007)
8.	Zhang, Yi-Hua: 1 article (12/2007)

Related Diseases

1.	Body Weight (Weight, Body) 12/22/2007 - "Importantly, in contrast to equimolar telmisartan, treatment with WB1106 significantly attenuated body weight gains and improved glucose tolerance in high-fat and carbohydrate-fed rats, reflecting a synergistic effect of NO and telmisartan. "
2.	Insulin Resistance 12/22/2007 - "Herein, the effects of [6-(nitrooxymethyl)pyridin-2-yl] methyl 4'-[1-(1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzo[d]imidazol-3'-yl)ethyl] biphenyl-2-carboxylate (WB1106), a novel NO-releasing derivative of telmisartan newly synthesized, on the vasocontraction, hypertension and diet-induced insulin resistance were examined in vitro using rat aortic strips and in normotensive and spontaneous hypertension rats (SHR rats). "
3.	Hypertension (High Blood Pressure) 12/22/2007 - "Potentially, WB1106 may be a potent anti-hypertensive drug for treatment of hypertension and diabetes-related cardiovascular diseases in the clinic." 12/22/2007 - "Herein, the effects of [6-(nitrooxymethyl)pyridin-2-yl] methyl 4'-[1-(1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzo[d]imidazol-3'-yl)ethyl] biphenyl-2-carboxylate (WB1106), a novel NO-releasing derivative of telmisartan newly synthesized, on the vasocontraction, hypertension and diet-induced insulin resistance were examined in vitro using rat aortic strips and in normotensive and spontaneous hypertension rats (SHR rats). " 12/22/2007 - "WB1106, a novel nitric oxide-releasing derivative of telmisartan, inhibits hypertension and improves glucose metabolism in rats."
4.	Cardiovascular Diseases (Cardiovascular Disease) 12/22/2007 - "Potentially, WB1106 may be a potent anti-hypertensive drug for treatment of hypertension and diabetes-related cardiovascular diseases in the clinic."

Related Drugs and Biologics

1.	Glucose (Dextrose)
2.	Carbohydrates
3.	Telmisartan (Micardis)
4.	Nitric Oxide (Nitrogen Monoxide)
5.	Antihypertensive Agents (Antihypertensives)