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8-nitroguanosine 3',5'-cyclic monophosphate

a signal for protein S-guanylation; structure in first source

Also Known As:

8-nitro-cGMP

Networked: 15 relevant articles (0 outcomes, 4 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Akaike, Takaaki: 13 articles (10/2016 - 02/2009)
2.	Sawa, Tomohiro: 10 articles (12/2013 - 02/2009)
3.	Fujii, Shigemoto: 7 articles (12/2013 - 02/2009)
4.	Okamoto, Tatsuya: 6 articles (01/2012 - 02/2009)
5.	Ihara, Hideshi: 4 articles (08/2012 - 07/2010)
6.	Arimoto, Hirokazu: 3 articles (01/2017 - 11/2012)
7.	Ida, Tomoaki: 3 articles (10/2016 - 07/2010)
8.	Yoshitake, Jun: 3 articles (10/2016 - 01/2012)
9.	Khan, Shahzada: 3 articles (12/2013 - 03/2009)
10.	Ahmed, Khandaker Ahtesham: 3 articles (01/2012 - 03/2009)

Related Diseases

1.	Glioma (Gliomas) 07/30/2010 - "In this study, we precisely quantified NO-dependent formation of 8-nitro-cGMP in C6 glioma cells via liquid chromatography-tandem mass spectrometry. " 08/01/2011 - "In the present study, we performed immunocytochemistry with monoclonal antibodies specific for 8-nitroguanine (clone NO2-52) and 8-nitro-cGMP (clone 1G6) in rat C6 glioma cells and rat primary cultured astrocytes. " 01/15/2012 - "Immunocytochemical and tandem mass spectrometric analyses revealed that formation of 8-nitro-cGMP in rat C6 glioma cells stimulated with lipopolysaccharide plus pro-inflammatory cytokines depended on production of both superoxide and H2O2. "
2.	Salmonella Infections (Salmonellosis) 01/01/2015 - "HO-1 induction was regulated solely by 8-nitro-cGMP formed in cells, and more important, its potent anti-apoptotic function was evident in such a Salmonella infection. " 03/15/2009 - "Our results suggest that HO-1 induced by NO-mediated 8-nitro-cGMP formation contributes, via its potent cytoprotective function, to host defense during murine salmonellosis." 02/01/2009 - "Moreover, a higher apoptosis was observed in iNOS-/- macrophages compared with wild-type macrophages after Salmonella infection, but the difference was nullified when iNOS-/- cells were treated with 8-nitro-cGMP. " 03/15/2009 - "In this study, we report a unique signal pathway for cytoprotection during Salmonella infection that involves heme oxygenase 1 (HO-1) induced by a nitrated cyclic nucleotide, 8-nitroguanosine 3',5'-cyclic monophosphate (8-nitro-cGMP). "
3.	Inflammation (Inflammations) 11/01/2012 - "The findings of this study collectively indicate that NO plays a crucial role not only in the production of 8-nitro-cGMP but also in its elimination under oxidative stress or inflammation." 12/26/2013 - "These results collectively indicate that 8-nitro-cGMP plays a crucial role in cytoprotection during bacterial infections or inflammations via autophagy upregulation." 11/01/2012 - "8-Nitro-cGMP is an endogenous nucleotide discovered under inflammation conditions as an important mediator of nitric oxide (NO) signaling. "
4.	Infections 01/01/2015 - "This review will discuss a new paradigm of the host defense that operates via formation of a unique cell signaling molecule, 8-nitro-cGMP, during microbial infections. " 01/01/2010 - "Here, we discuss the unique mechanism of NO-mediated host defense that operates via formation of a novel signaling molecule - 8-nitro-cGMP - during microbial infections." 02/01/2009 - "In this review, we focus on a unique mechanism of NO-mediated host defense via formation of a novel signaling molecule, 8-nitro-cGMP in microbial infections."
5.	Myocardial Infarction 08/01/2012 - "The relevance of this reaction is reinforced by the significant 8-nitro-cGMP formation in mouse cardiac tissue after myocardial infarction that is modulated by alterations in HS(-) biosynthesis. " 01/01/2014 - "A significant amount of 8-nitro-cGMP was formed in the heart tissue after myocardial infarction, and hydrogen sulfide exogenously administered completely nullified this formation. "

Related Drugs and Biologics

1.	Heme Oxygenase-1
2.	Cyclic Nucleotides
3.	Monoclonal Antibodies
4.	8-nitroguanine
5.	Nitric Oxide (Nitrogen Monoxide)
6.	Cytokines
7.	Superoxides (Superoxide)
8.	Nucleotides
9.	Lipopolysaccharides
10.	Hydrogen Sulfide (Sulfide, Hydrogen)