M62812

toll-like receptor 4 signal transduction inhibitor that suppresses endothelial cell and leukocyte activation and prevents lethal septic shock; structure in first source

Also Known As:

3-amino-6-(2-aminophenoxy)-1,2-benzisothiazole dihydrochloride

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Sulfur Compounds: 278
  - Thiazoles: 392
    - M62812: 2
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Thiazoles: 392
      - M62812: 2

Experts

1.	Beom, Jaewon: 1 article (10/2020)
2.	Hong, Jinpyo: 1 article (10/2020)
3.	Joo, Yongbum: 1 article (10/2020)
4.	Kim, Dong Woon: 1 article (10/2020)
5.	Kim, Jinhyun: 1 article (10/2020)
6.	Kim, Youngmo: 1 article (10/2020)
7.	Kwon, Hyeok Hee: 1 article (10/2020)
8.	Park, Hyewon: 1 article (10/2020)
9.	Shin, Hyo Jung: 1 article (10/2020)
10.	Shin, Juhee: 1 article (10/2020)

Related Diseases

1.	Septic Shock (Toxic Shock Syndrome) 08/27/2007 - "Toll-like receptor 4 signal transduction inhibitor, M62812, suppresses endothelial cell and leukocyte activation and prevents lethal septic shock in mice." 08/27/2007 - "The half maximal inhibitory concentrations in these assays ranged from 1 to 3 microg/ml. Single intravenous administration of M62812 (10-20 mg/kg) protected mice from lethality and reduced inflammatory and coagulatory parameters in a murine d-galactosamine-sensitized endotoxin shock model. "
2.	Pain (Aches) 10/15/2020 - "Moreover, interestingly, the duration of OA pain relief by TAP2 was much longer than that of chemical TLR4 antagonists, such as C34 and M62812. "

Related Drugs and Biologics

1.	Toll-Like Receptor 4
2.	Galactosamine

Related Therapies and Procedures

1.	Intravenous Administration