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6,7- dihydro- 4- hydroxy- 7- isopropyl- 6- oxo- N- (3- (piperidin- 1- yl)propyl)thieno(2,3- b)pyridine- 5- carboxamide

Subscribe to New Research on 6,7-dihydro-4-hydroxy-7-isopropyl-6-oxo-N-(3-(piperidin-1-yl)propyl)thieno(2,3-b)pyridine-5-carboxamide

VRX-03011 is the potassium salt; structure in first source

Also Known As:

VRX 03011; VRX-03011; VRX03011

Networked: 1 relevant articles (1 outcomes, 0 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Gold, Paul E: 1 article (09/2007)
2.	Mohler, Eric G: 1 article (09/2007)
3.	Ragozzino, Michael E: 1 article (09/2007)
4.	Bockaert, Joel: 1 article (09/2007)
5.	Gastineau, Monique: 1 article (09/2007)
6.	Marantz, Yael: 1 article (09/2007)
7.	Rutkowski, Joseph: 1 article (09/2007)
8.	Shacham, Sharon: 1 article (09/2007)
9.	Robert, Sylvain: 1 article (09/2007)
10.	Noiman, Silvia: 1 article (09/2007)

Related Diseases

1.

Alzheimer Disease (Alzheimer's Disease)

09/01/2007 - "VRX-03011 also regulated amyloid precursor protein (APP) metabolism by inducing a concentration-dependent increase in the non-amyloidogenic soluble form of APP (sAPPalpha) with an EC(50) approximately 1--10 nM. VRX-03011 had no effect on contractile properties in guinea pig ileum or colon preparations with an EC(50) > 10 microM and did not alter rat intestinal transit at doses up to 10 mg/kg. These findings suggest that VRX-03011 may represent a novel treatment for Alzheimer's disease that reduces cognitive impairments and provides neuroprotection without gastrointestinal side effects."

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