C(alpha)-formylglycine

An unusual amino acid residue found at active site of sulfatases. It is created through the conversion of an active site cysteine or serine residue by C(alpha)-formylglycine (FGly)-generating enzyme. Although the term formylglycine has been used in the literature to refer to C(alpha)-formylglycine it is found in most chemical sources as a synonom for N-formyglycine.

Also Known As:

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Dierks, Thomas: 2 articles (10/2003 - 05/2003)
2.	Schmidt, Bernhard: 2 articles (10/2003 - 05/2003)
3.	von Figura, Kurt: 2 articles (10/2003 - 05/2003)
4.	Harasink, Sue Moyer: 1 article (04/2016)
5.	Khurana, Divya S: 1 article (04/2016)
6.	Legido, Agustin: 1 article (04/2016)
7.	Melvin, Joseph J: 1 article (04/2016)
8.	Miskin, Chandrabhaga: 1 article (04/2016)
9.	Wenger, David A: 1 article (04/2016)
10.	Annunziata, I: 1 article (11/2005)

Related Diseases

1.	Multiple Sulfatase Deficiency Disease (Mucosulfatidosis) 05/16/2003 - "Multiple sulfatase deficiency is caused by mutations in the gene encoding the human C(alpha)-formylglycine generating enzyme." 10/16/2003 - "Recently, the human C(alpha)-formylglycine (FGly)-generating enzyme (FGE), whose deficiency causes the autosomal-recessively transmitted lysosomal storage disease multiple sulfatase deficiency (MSD), has been identified. " 04/01/2016 - "Multiple sulfatase deficiency is an autosomal recessive lysosomal storage disorder characterized by the absence of several sulfatases and resulting from mutations in the gene encoding the human C (alpha)-formylglycine-generating enzyme. " 11/01/2005 - "Several human inherited diseases are caused by the deficiency of individual sulfatases, while in patients with multiple sulfatase deficiency mutations in the Sulfatase Modifying Factor 1 (SUMF1) gene cause a defect in the post-translational modification of a cysteine residue into C(alpha)-formylglycine (FGly) at the active site of all sulfatases. " 05/16/2003 - "The posttranslational conversion of cysteine to C(alpha)-formylglycine in the catalytic site of mammalian sulfatases is deficient in the rare but devastating disorder multiple sulfatase deficiency (MSD). "
2.	Lysosomal Storage Diseases (Lysosomal Storage Disease) 10/16/2003 - "Recently, the human C(alpha)-formylglycine (FGly)-generating enzyme (FGE), whose deficiency causes the autosomal-recessively transmitted lysosomal storage disease multiple sulfatase deficiency (MSD), has been identified. "

Related Drugs and Biologics

1.	Sulfatases
2.	Enzymes
3.	Cysteine (L-Cysteine)