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GI270384X

a methyl-capped polyethylene glycol derivative of (E)-4-1,3-bis-(cyclohexylmethyl)-1,2,3,6-tetrahydro-2,6-dioxo-9H-purin-8-yl for the treatment of experimental colitis

Networked: 2 relevant articles (1 outcomes, 1 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Gebhart, G F: 1 article (02/2009)
2.	Greenwood-van Meerveld, B: 1 article (02/2009)
3.	Hicks, G A: 1 article (02/2009)
4.	Johnson, A: 1 article (02/2009)
5.	McLean, P G: 1 article (02/2009)
6.	Winchester, W J: 1 article (02/2009)
7.	Aceituno, Montserrat: 1 article (10/2007)
8.	Gil, Fèlix: 1 article (10/2007)
9.	McLean, Peter: 1 article (10/2007)
10.	Miquel, Rosa: 1 article (10/2007)

Related Diseases

1.	Colitis 10/01/2007 - "These results indicate that GI270384X is effective in the treatment of experimental colitis of moderate severity. " 10/01/2007 - "Efficacy of an inhibitor of adhesion molecule expression (GI270384X) in the treatment of experimental colitis." 10/01/2007 - "This study evaluates the effects of an inhibitor of adhesion molecule expression (GI270384X) in two experimental models of colitis. " 10/01/2007 - "GI270384X (3, 10, or 25 mg.kg(-1).day(-1)) was administered as pretreatment or started 3 days after colitis induction. " 10/01/2007 - "In the most severe forms of colitis (2% and 3% DSS and IL-10-deficient mice), the magnitude of colonic inflammation was not modified by treatment with GI270384X. "
2.	Inflammation (Inflammations) 10/01/2007 - "In the most severe forms of colitis (2% and 3% DSS and IL-10-deficient mice), the magnitude of colonic inflammation was not modified by treatment with GI270384X. "
3.	Hypersensitivity (Allergy) 02/01/2009 - "GI270384X attenuated the enhanced responses to distension induced by inflammatory stimuli (TNBS and zymosan) and in the high-anxiety WKY rats; however, the drug did not inhibit the hypersensitivity induced by acute restraint stress. "

Related Drugs and Biologics

1.	E-Selectin
2.	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)
3.	Biomarkers (Surrogate Marker)
4.	Zymosan
5.	Serum Amyloid A Protein (Serum Amyloid A)