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1- benzyl- 3- pentyl- 2- (6- (1H- tetrazol- 5- ylmethoxy)naphthalen- 2- yl)- 1H- indole

structure in first source

Also Known As:

PAI 749; PAI-749; PAI749

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Tetrazoles: 14
      - 1-benzyl-3-pentyl-2-(6-(1H-tetrazol-5-ylmethoxy)naphthalen-2-yl)-1H-indole: 1
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - 1-benzyl-3-pentyl-2-(6-(1H-tetrazol-5-ylmethoxy)naphthalen-2-yl)-1H-indole: 1

Experts

1.	Booth, N A: 1 article (06/2010)
2.	Connolly, T M: 1 article (06/2010)
3.	Feuerstein, G Z: 1 article (06/2010)
4.	Fox, K A A: 1 article (06/2010)
5.	Fraser, S: 1 article (06/2010)
6.	Gardell, S J: 1 article (06/2010)
7.	Grant, P J: 1 article (06/2010)
8.	Lucking, A J: 1 article (06/2010)
9.	Newby, D E: 1 article (06/2010)
10.	Philippou, H: 1 article (06/2010)

Related Diseases

1.

Thrombosis (Thrombus)

06/01/2010 - "Despite its efficacy in a purified human system and in preclinical models of thrombosis, the current study suggests that PAI-749 does not affect thrombus formation or fibrinolysis in a range of established human plasma and whole blood-based systems."
06/01/2010 - "PAI-749 had no effect on in vitro or ex vivo thrombus formation or fibrinolysis in the presence or absence of t-PA. "
06/01/2010 - "To assess the effect of PAI-749, by using an established ex vivo clinical model of thrombosis and a range of complementary in vitro human plasma-based and whole blood-based models of fibrinolysis. "
06/01/2010 - "In a double-blind, randomized, crossover study, ex vivo thrombus formation was assessed using the Badimon chamber in 12 healthy volunteers during extracorporeal administration of tissue-type plasminogen activator (t-PA) in the presence of PAI-749 or control. "

Related Drugs and Biologics

1.	Tissue Plasminogen Activator (Alteplase)