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CPT417

CPT417 shows dramatically reduced toxicity and an enhanced antitumor activity compared to topotecan

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Alkaloids: 5398
  - Camptothecin: 2033
    - CPT417: 2

Experts

1.	Wang, Hui-Juan: 2 articles (11/2016 - 09/2007)
2.	Yang, Li-Xi: 2 articles (11/2016 - 09/2007)
3.	Yount, Garret: 2 articles (11/2016 - 09/2007)
4.	Luu, Tran: 1 article (11/2016)
5.	Singer, Eric: 1 article (11/2016)
6.	Soroceanu, Liliana: 1 article (11/2016)
7.	Yount, Romi: 1 article (11/2016)
8.	Wong, Brian: 1 article (09/2007)
9.	Yang, Yang: 1 article (09/2007)

Related Diseases

1.	Glioblastoma (Glioblastoma Multiforme) 11/01/2016 - "In this pilot study, we assessed the activity of CPT417 against glioblastoma multiforme (GBM) cells and glioma stem cells. " 09/01/2007 - "The anticancer effects of CPT417 were assessed in vitro, with glioblastoma and colon cancer cell lines, and in vivo with mice bearing mammary adenocarcinoma tumors implanted subcutaneously in the flank. " 09/01/2007 - "CPT417 and topotecan inhibited glioblastoma cell growth at comparable levels and both compounds inhibited clonogenicity of colon cancer cells more effectively than irinotecan. "
2.	Neoplasms (Cancer) 09/01/2007 - "CPT417 showed a much greater inhibition of mammary tumor growth compared to topotecan, both by intraperitoneal and oral administration. " 09/01/2007 - "The anticancer effects of CPT417 were assessed in vitro, with glioblastoma and colon cancer cell lines, and in vivo with mice bearing mammary adenocarcinoma tumors implanted subcutaneously in the flank. "
3.	Glioma (Gliomas) 11/01/2016 - "Cell viability of a glioma stem cell line was assessed 5 days after exposure to a range of CPT417 concentrations. " 11/01/2016 - "In this pilot study, we assessed the activity of CPT417 against glioblastoma multiforme (GBM) cells and glioma stem cells. " 11/01/2016 - "Cell viability analysis of glioma stem cell cultures yielded a half-maximal response at 15 nM. CPT417 acts selectively against GBM cells at concentrations that are at least an order of magnitude below reported values for related alkylating agents in clinical use."
4.	Colonic Neoplasms (Colon Cancer) 09/01/2007 - "The anticancer effects of CPT417 were assessed in vitro, with glioblastoma and colon cancer cell lines, and in vivo with mice bearing mammary adenocarcinoma tumors implanted subcutaneously in the flank. " 09/01/2007 - "CPT417 and topotecan inhibited glioblastoma cell growth at comparable levels and both compounds inhibited clonogenicity of colon cancer cells more effectively than irinotecan. "
5.	Adenocarcinoma 09/01/2007 - "The anticancer effects of CPT417 were assessed in vitro, with glioblastoma and colon cancer cell lines, and in vivo with mice bearing mammary adenocarcinoma tumors implanted subcutaneously in the flank. "

Related Drugs and Biologics

1.	Topotecan (Hycamtin)
2.	Alkylating Agents
3.	Irinotecan (Camptosar)

Related Therapies and Procedures

1.	Oral Administration