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4'-bromo-3'-nitropropiophenone

structure in first source

Also Known As:

NS-123

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Ketones: 2618
  - Propiophenones: 1
    - 4'-bromo-3'-nitropropiophenone: 1

Experts

1.	Arcury-Quandt, Alice E: 1 article (09/2007)
2.	Geiger, Geoffrey A: 1 article (09/2007)
3.	Georgakilas, Alexandros: 1 article (09/2007)
4.	Kao, Gary D: 1 article (09/2007)
5.	Kock, Nancy D: 1 article (09/2007)
6.	Koumenis, Constantinos: 1 article (09/2007)
7.	Kridel, Steven: 1 article (09/2007)
8.	Lally, Brian E: 1 article (09/2007)
9.	Peddi, Prakash: 1 article (09/2007)
10.	Robbins, Michael E: 1 article (09/2007)

Related Diseases

1.	Colorectal Neoplasms (Colorectal Cancer) 09/15/2007 - "HT-29 colorectal carcinoma and A549 lung adenocarcinoma cells were also radiosensitized by NS-123 in vitro, whereas NS-123 did not increase the radiation sensitivity of normal human astrocytes or developmental abnormalities or lethality of irradiated Zebrafish embryos. "
2.	Neoplasms (Cancer) 09/15/2007 - "Similar results were obtained using a mouse tumor xenograft model in which NS-123 sensitized U251 tumors to IR while exhibiting no overt toxicity. " 09/15/2007 - "In a novel xenograft model of U251 cells implanted into Zebrafish embryos, NS-123 enhanced the tumor growth-inhibitory effects of ionizing radiation (IR) with no apparent effect on embryo development. "
3.	Glioma (Gliomas) 09/15/2007 - "NS-123 radiosensitized U251 glioma cells in a dose-dependent and time-dependent manner, with dose enhancement ratios ranging from 1.3 to 2.0. " 09/15/2007 - "Using a high-throughput, unbiased screening approach, we have identified 4'-bromo-3'-nitropropiophenone (NS-123) as a radiosensitizer of human glioma cells in vitro and in vivo. "
4.	Ataxia Telangiectasia (Louis Bar Syndrome) 09/15/2007 - "In vitro pretreatment with NS-123 resulted in accumulation of unrepaired IR-induced DNA strand breaks and prolonged phosphorylation of the surrogate markers of DNA damage H2AX, ataxia telangiectasia mutated protein, DNA-dependent protein kinase, and CHK2 after IR, suggesting that NS-123 inhibits a critical step in the DNA repair pathway. "
5.	Adenocarcinoma of Lung 09/15/2007 - "HT-29 colorectal carcinoma and A549 lung adenocarcinoma cells were also radiosensitized by NS-123 in vitro, whereas NS-123 did not increase the radiation sensitivity of normal human astrocytes or developmental abnormalities or lethality of irradiated Zebrafish embryos. "

Related Drugs and Biologics

1.	DNA-Activated Protein Kinase
2.	Biomarkers (Surrogate Marker)
3.	Proteins (Proteins, Gene)
4.	DNA (Deoxyribonucleic Acid)