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naphthalen- 1- yl- (4- pentyloxynaphthalen- 1- yl)methanone

has antihyperalgesic activity; structure in first source

Also Known As:

1-naphthalenyl(4-(pentyloxy)-1-naphthalenyl)methanone; CB-13; CB13 compound

Networked: 4 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Naphthalenes: 18
        naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone: 4
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Naphthalenes: 18
    - naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone: 4

Experts

1.	Barpujari, Awinita: 1 article (01/2022)
2.	Brings, Victoria E: 1 article (01/2022)
3.	Dong, Xinzhong: 1 article (01/2022)
4.	Ford, Neil C: 1 article (01/2022)
5.	Gereau, Robert W: 1 article (01/2022)
6.	Guan, Yun: 1 article (01/2022)
7.	He, Shao-Qiu: 1 article (01/2022)
8.	Huang, Qian: 1 article (01/2022)
9.	Huynh, Phuong Nhu: 1 article (01/2022)
10.	Raja, Srinivasa N: 1 article (01/2022)

Related Diseases

1.	Inflammation (Inflammations) 01/01/2022 - "CB-13 reduced inflammation-induced mechanical allodynia in male and female mice in a peripheral CB 1 -receptor-dependent manner and relieved inflammatory thermal hyperalgesia. "
2.	Hyperalgesia 01/01/2022 - "With acute dosing, phenotypes associated with central CB 1 receptor activation occurred only at a dose of CB-13 approximately 10-fold the ED 50 for reducing allodynia. " 01/01/2022 - "CB-13 reduced inflammation-induced mechanical allodynia in male and female mice in a peripheral CB 1 -receptor-dependent manner and relieved inflammatory thermal hyperalgesia. "
3.	Pain (Aches) 01/01/2022 - "In the present study, we evaluated the effects of acute and repeated dosing with the peripherally selective CB 1 -preferring agonist CB-13 on nociception and central CB 1 -related phenotypes in a model of inflammatory pain in mice. " 01/01/2022 - "Systemic administration of CB-13, a peripherally restricted CB1/CB2R dual agonist (5 mg kg-1), inhibited nociceptive pain and complete Freund adjuvant-induced inflammatory pain. " 01/01/2022 - "Role of primary sensory neurone cannabinoid type-1 receptors in pain and the analgesic effects of the peripherally acting agonist CB-13 in mice."
4.	Nociceptive Pain 01/01/2022 - "Systemic administration of CB-13, a peripherally restricted CB1/CB2R dual agonist (5 mg kg-1), inhibited nociceptive pain and complete Freund adjuvant-induced inflammatory pain. "
5.	Hypertrophy 11/01/2014 - "In conclusion, CB-13 inhibits cardiomyocyte hypertrophy through AMPK-eNOS signaling and may represent a novel therapeutic approach to cardioprotection. "

Related Drugs and Biologics

1.	Cannabinoids
2.	CB2 Cannabinoid Receptor
3.	Cannabinoid Receptors (Cannabinoid Receptor)
4.	Freund's Adjuvant
5.	Analgesics (Analgesic Drugs)
6.	nabiximols (Sativex)