withanoside IV

a withanolide glycoside from Ashwagantha (root of Withania somnifera), an Ayurvedic medicine; improves hindlimb function by facilitating axonal growth and increase in peripheral nervous system myelin level after spinal cord injury

Networked: 7 relevant articles (3 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Tohda, Chihiro: 5 articles (08/2009 - 06/2002)
2.	Dubey, Shreya: 2 articles (03/2021 - 01/2018)
3.	Kallubai, Monika: 2 articles (03/2021 - 01/2018)
4.	Subramanyam, Rajagopal: 2 articles (03/2021 - 01/2018)
5.	Komatsu, Katsuko: 2 articles (03/2006 - 06/2002)
6.	Kuboyama, Tomoharu: 2 articles (03/2006 - 06/2002)
7.	Sarkar, Arijit: 1 article (01/2018)
8.	Joyashiki, Eri: 1 article (08/2009)
9.	Nakayama, Natsuki: 1 article (06/2007)
10.	Hattori, Masao: 1 article (06/2002)

Related Diseases

1.	Memory Disorders (Memory Loss) 03/01/2006 - "Oral administration of withanoside IV (10 micromol/kg/day) significantly improved memory deficits in Abeta(25-35)-injected (25 nmol, i.c.v.) mice and prevented loss of axons, dendrites, and synapses. " 08/01/2009 - "Orally administered withanoside IV (a compound isolated from the roots of Withania somnifera) improved memory deficits in mice with a model of Alzheimer's disease induced by the amyloid peptide Abeta(25-35). "
2.	Alzheimer Disease (Alzheimer's Disease) 03/01/2006 - "These data suggest that orally administrated withanoside IV may ameliorate neuronal dysfunction in Alzheimer's disease and that the active principle after metabolism is sominone." 08/01/2009 - "Orally administered withanoside IV (a compound isolated from the roots of Withania somnifera) improved memory deficits in mice with a model of Alzheimer's disease induced by the amyloid peptide Abeta(25-35). " 03/15/2021 - "Here, we have studied the ameliorative effects of Withania somnifera derivatives (Withanolide A, Withanolide B, Withanoside IV, and Withanoside V) on the fibril formation of amyloid-β 42 for Alzheimer's disease. "
3.	Neurodegenerative Diseases (Neurodegenerative Disease) 08/01/2008 - "Withanolide A, withanoside IV, and withanoside VI are therefore important candidates for the therapeutic treatment of neurodegenerative diseases. "
4.	Atrophy 08/01/2008 - "In vivo, oral withanolide A, withanoside IV, and withanoside VI (10 micromol/kg/day for 12 days) improved Abeta(25-35)-induced memory impairment, neurite atrophy, and synaptic loss in the cerebral cortex and hippocampus in mice. "
5.	Rheumatic Diseases (Rheumatism) 01/01/2018 - "Withania somnifera (Ashwagandha) is an efficient medicinal plant known in Ayurveda and Chinese medicine since ancient times, whose extracts are consumed orally as food supplement or as a health tonic owing to its several restorative properties for various CNS disorders, inflammation, tumour, stress, rheumatism etc. In this study, we have analyzed the binding interaction of four derivatives of Withania somnifera (Withanolide A, Withanolide B, Withanoside IV and Withanoside V) with HSA because of their important pharmacological properties. "

Related Drugs and Biologics

1.	3- rhamnopyranosyl(1- 4)- glucopyranosyl- 12- diacetoxy- 20- hydroxywitha- 5,24- dienolide
2.	Amyloid (Amyloid Fibrils)
3.	Peptides (Polypeptides)
4.	withanolide B
5.	withanoside V
6.	Ashwagandha
7.	sominone
8.	Thromboplastin (Tissue Factor)

Related Therapies and Procedures

1.	Oral Administration