TEM8-Fc

an engineered antibody-like molecule targeting tumor endothelial marker 8 that consists of the protective antigen (PA)-binding domain of human TEM8 linked to the Fc portion of human immunoglobulin G1; has antitumor activity

Also Known As:

tumor endothelial marker 8-Fc

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
- Peptides: 82426
  - Peptide Fragments: 373
    - Immunoglobulin Fragments: 976
      - Immunoglobulin Fc Fragments: 295
        TEM8-Fc: 2

Experts

1.	Chen, Hui-Peng: 2 articles (01/2018 - 10/2007)
2.	Chen, Wei: 2 articles (01/2018 - 10/2007)
3.	Duan, Hai-Feng: 2 articles (01/2018 - 10/2007)
4.	Gao, Li-Hua: 2 articles (01/2018 - 10/2007)
5.	Hu, Xian-Wen: 2 articles (01/2018 - 10/2007)
6.	Xi, Yong-Yi: 2 articles (01/2018 - 10/2007)
7.	Liu, Jin: 1 article (01/2018)
8.	Shao, Yong: 1 article (01/2018)
9.	Wang, You-Liang: 1 article (01/2018)
10.	Wu, Chutse: 1 article (01/2018)

Related Diseases

1.	Neoplasm Metastasis (Metastasis) 10/17/2007 - "TEM8-Fc suppressed the growth and metastasis of xenograft human tumors in athymic nude mice (control versus 10 mg/kg TEM8-Fc, mean tumor weight: LS-180, 1.72 versus 0.16 g, difference = 1.56 g, 95% confidence interval [CI] = 0.96 to 2.16 g; P<.001; MCF-7, 1.12 versus 0.08 g, difference = 1.04 g, 95% CI = 0.77 to 1.31 g; P<.001; HepG2, 1.28 versus 0.35 g, difference = 0.93 g, 95% CI = 0.60 to 1.25 g; P<.001). " 01/01/2018 - "Binding of uPA stimulated the phosphorylation of TEM8 and augmented phosphorylation of EGFR and ERK1/2. Finally, TEM8-Fc, a recombinant fusion protein comprising the extracellular domain of human TEM8 linked to the Fc portion of human IgG1, efficiently abrogated the interaction between uPA and TEM8, blocked uPA-induced migration of HepG2 cells in vitro and inhibited the growth and metastasis of human MCF-7 xenografts in vivo. "
2.	Neoplasms (Cancer) 10/17/2007 - "TEM8-Fc is a novel therapeutic antibody-like agent in the management of solid tumors that may act by trapping M2-PK." 10/17/2007 - "TEM8-Fc suppressed the growth and metastasis of xenograft human tumors in athymic nude mice (control versus 10 mg/kg TEM8-Fc, mean tumor weight: LS-180, 1.72 versus 0.16 g, difference = 1.56 g, 95% confidence interval [CI] = 0.96 to 2.16 g; P<.001; MCF-7, 1.12 versus 0.08 g, difference = 1.04 g, 95% CI = 0.77 to 1.31 g; P<.001; HepG2, 1.28 versus 0.35 g, difference = 0.93 g, 95% CI = 0.60 to 1.25 g; P<.001). "

Related Drugs and Biologics

1.	Recombinant Fusion Proteins
2.	Immunoglobulin G (IgG)