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16alpha- bromo- 3beta- hydroxy- 5alpha- androstan- 17- one

a synthetic adrenal hormone that reduced the incidence of tuberculosis and other opportunistic infections in AIDS patients

Also Known As:

HE2000

Networked: 5 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Frincke, J: 2 articles (12/2009 - 11/2006)
2.	Stickney, D: 2 articles (12/2009 - 11/2006)
3.	Frincke, James M: 2 articles (07/2007 - 02/2007)
4.	Garsd, Armando: 2 articles (07/2007 - 02/2007)
5.	Stickney, Dwight R: 2 articles (07/2007 - 02/2007)
6.	Pai, Roopa S: 1 article (06/2015)
7.	Singh, Gurinder: 1 article (06/2015)
8.	Auci, D L: 1 article (12/2009)
9.	Conrad, D: 1 article (12/2009)
10.	Mangano, K: 1 article (12/2009)

Related Diseases

1.	Tuberculosis (Tuberculoses) 07/01/2007 - "Safety and activity of the immune modulator HE2000 on the incidence of tuberculosis and other opportunistic infections in AIDS patients." 12/01/2009 - "16alpha-Bromoepiandrosterone (HE2000) is a synthetic steroid that limits non-productive inflammation, enhances protective immunity and improves survival in clinical studies of patients with human immunodeficiency virus (HIV), malaria and tuberculosis infections. " 02/01/2007 - "16alpha-Bromoepiandrosterone (HE2000) is a synthetic androstane steroid that has immune effects in pre-clinical models of malaria, tuberculosis, and infection with human immunodeficiency virus. "
2.	Malaria 02/01/2007 - "Reduction of parasite levels in patients with uncomplicated malaria by treatment with HE2000." 02/01/2007 - "HE2000 shows a safety profile and pharmacologic activity worthy of further investigation to understand its role in the treatment of malaria, perhaps in combination with anti-malarial agents." 12/01/2009 - "16alpha-Bromoepiandrosterone (HE2000) is a synthetic steroid that limits non-productive inflammation, enhances protective immunity and improves survival in clinical studies of patients with human immunodeficiency virus (HIV), malaria and tuberculosis infections. " 02/01/2007 - "16alpha-Bromoepiandrosterone (HE2000) is a synthetic androstane steroid that has immune effects in pre-clinical models of malaria, tuberculosis, and infection with human immunodeficiency virus. "
3.	Infections 12/01/2009 - "In H1N1 infection in mice, HE2000 was safe but not effective as a monotherapy, as treatment did not effect survival. " 12/01/2009 - "HE2000 reduced mortality related to excessive inflammation and opportunistic lung infections in animals and patients, and this might extend to those with H1N1 influenza infection." 12/01/2009 - "16alpha-Bromoepiandrosterone (HE2000) is a synthetic steroid that limits non-productive inflammation, enhances protective immunity and improves survival in clinical studies of patients with human immunodeficiency virus (HIV), malaria and tuberculosis infections. " 02/01/2007 - "16alpha-Bromoepiandrosterone (HE2000) is a synthetic androstane steroid that has immune effects in pre-clinical models of malaria, tuberculosis, and infection with human immunodeficiency virus. "
4.	Inflammation (Inflammations) 12/01/2009 - "16alpha-Bromoepiandrosterone (HE2000) limits non-productive inflammation and stimulates immunity in lungs." 12/01/2009 - "HE2000 reduced mortality related to excessive inflammation and opportunistic lung infections in animals and patients, and this might extend to those with H1N1 influenza infection." 12/01/2009 - "Treatment with HE2000 also reduced non-productive inflammation associated with carrageenan-induced pleurisy and LPS-induced lung injury in mice. " 12/01/2009 - "16alpha-Bromoepiandrosterone (HE2000) is a synthetic steroid that limits non-productive inflammation, enhances protective immunity and improves survival in clinical studies of patients with human immunodeficiency virus (HIV), malaria and tuberculosis infections. "
5.	Acquired Immunodeficiency Syndrome (AIDS) 07/01/2007 - "Twenty-five AIDS patients were treated with HE2000, a synthetic adrenal hormone. " 07/01/2007 - "Safety and activity of the immune modulator HE2000 on the incidence of tuberculosis and other opportunistic infections in AIDS patients." 06/01/2015 - "The present review first describes the boon of antioxidants (especially Vitamin A) and immune modulators (cytolin, resveratrol, murabutide, setarud, tucaresol, AVR118, Immunitin (HE2000), reticulose, and interleukin-7) in the treatment of HIV/AIDS. "

Related Drugs and Biologics

1.	Steroids
2.	Cystic Fibrosis Transmembrane Conductance Regulator (Protein, CFTR)
3.	Interleukin-7 (Interleukin 7)
4.	Vitamin A (Retinol)
5.	Hormones (Hormone)
6.	Carrageenan
7.	Antioxidants
8.	Antimalarials (Antimalarial Agents)
9.	Resveratrol
10.	setarud

Related Therapies and Procedures

1.	Intramuscular Injections
2.	Buccal Administration