HOME PRODUCTS SERVICES COMPANY CONTACT FAQ

CJ-023,423

a potent and selective prostaglandin EP4 receptor antagonist with antihyperalgesic properties; structure in first source

Also Known As:

CJ-023423; N-(((2-(4-(2-ethyl-4,6-dimethyl-1H-imidazo(4,5-c)pyridin-1-yl) phenyl)ethyl)amino)carbonyl)-4-methylbenzenesulfonamide

Networked: 2 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 58
- Amides: 231
  - Sulfonamides: 931
    - CJ-023,423: 2
- Sulfur Compounds: 135
  - Sulfones: 136
    - Sulfonamides: 931
      - CJ-023,423: 2

Experts

1.	Murase, Akio: 2 articles (06/2008 - 08/2007)
2.	Okumura, Takako: 2 articles (06/2008 - 08/2007)
3.	Taniguchi, Kana: 2 articles (06/2008 - 08/2007)
4.	Murata, Yoko: 2 articles (06/2008 - 08/2007)
5.	Nii, Aisuke: 1 article (06/2008)
6.	Okumura, Yoshiyuki: 1 article (08/2007)
7.	Masuda, Masatoshi: 1 article (08/2007)
8.	Takada, Junji: 1 article (08/2007)
9.	Kato, Tomoki: 1 article (08/2007)
10.	Ohshiro, Hiroyuki: 1 article (08/2007)

Related Diseases

1.	Pain (Aches) 08/01/2007 - "CJ-023,423 is also effective in models of acute and chronic inflammatory pain. " 08/01/2007 - "Taken together, the present data indicate that CJ-023,423, a highly potent and selective antagonist of both human and rat EP(4) receptors, produces antihyperalgesic effects in animal models of inflammatory pain. " 08/01/2007 - "Furthermore, CJ-023,423 significantly reverses complete Freund's adjuvant-induced chronic inflammatory pain response. "
2.	Inflammation 06/01/2008 - "In this study, CJ-023,423 was used in rats with adjuvant-induced arthritis (AIA) to investigate the role of the EP4 receptor in chronic inflammation and bone destruction. " 06/01/2008 - "Effects of the selective EP4 antagonist, CJ-023,423 on chronic inflammation and bone destruction in rat adjuvant-induced arthritis." 06/01/2008 - "CJ-023,423 had significant inhibitory effects on paw swelling, inflammatory biomarkers, synovial inflammation and bone destruction in AIA rats. "
3.	Arthritis (Polyarthritis) 06/01/2008 - "In this study, CJ-023,423 was used in rats with adjuvant-induced arthritis (AIA) to investigate the role of the EP4 receptor in chronic inflammation and bone destruction. " 06/01/2008 - "Effects of the selective EP4 antagonist, CJ-023,423 on chronic inflammation and bone destruction in rat adjuvant-induced arthritis."
4.	Hyperalgesia 08/01/2007 - "CJ-023,423 significantly reduces mechanical hyperalgesia in the carrageenan model. " 08/01/2007 - "In vivo, oral administration of CJ-023,423 significantly reduces thermal hyperalgesia induced by intraplantar injection of PGE(2) (ED(50) = 12.8 mg/kg). "

Related Drugs and Biologics

1.	Biological Markers (Surrogate Marker)
2.	Prostaglandins E (PGE)
3.	Freund's Adjuvant
4.	Carrageenan

Related Therapies and Procedures

1.	Oral Administration