biflorin

08/01/2016 - "roots that is cytotoxic in vitro and in vivo, this study aimed to demonstrate the action of biflorin against three established human melanoma cell lines that recapitulate the molecular landscape of the disease in terms of genetic alterations and mutations, such as the TP53, NRAS and BRAF genes. "
04/01/2011 - "The aim of this study was to examine the effectiveness of biflorin treatment using both in-vitro and in-vivo melanoma models. "
08/01/2016 - "Our data suggest that biflorin could be considered as a future therapeutic option for managing melanoma. "
08/14/2013 - "These data suggest that biflorin has a promising antimetastatic potential, as shown by its anti-adhesion, anti-migration and anti-invasion properties against a metastatic melanoma cell line. "
08/14/2013 - "Inhibition of metastatic potential of B16-F10 melanoma cell line in vivo and in vitro by biflorin."

08/14/2013 - "The administration of biflorin at 25mg/kg/day intraperitoneally inhibited the formation of metastases by about 57% compared to untreated control animals. "
08/14/2013 - "Treatment with biflorin (25 and 50mg/kg/day) was shown to be effective in reducing B16-F10 melanoma metastasis in C57BL/6 mice. "

12/21/2015 - "In this study, the cytotoxic effects of biflorin were verified, and late apoptosis was detected in various cancer cell lines by in situ analysis. "
12/21/2015 - "The results indicated that biflorin induced selective cytotoxicity in tumor cells. "
04/01/2011 - "It has been reported that biflorin presents anticancer activity, inhibiting both tumor cell line growth in culture and tumor development in mice. "
08/01/2007 - "Biflorin was active against both tumors with a very similar profile. "
08/01/2007 - "It has been demonstrated that biflorin possesses an in vitro cytotoxic activity against tumor cells. "

03/01/2020 - "Our findings suggest a novel molecular target of biflorin in ACP02 cells, which may be a significant therapeutic approach for gastric cancer management."
03/01/2020 - "Biflorin inhibits the proliferation of gastric cancer cells by decreasing MYC expression."

04/22/2016 - "Biflorin, Isolated from the Flower Buds of Syzygium aromaticum L., Suppresses LPS-Induced Inflammatory Mediators via STAT1 Inactivation in Macrophages and Protects Mice from Endotoxin Shock."