HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

AS604872

a small molecule selective antagonist of the FP receptor

Also Known As:

(2S)-3-((1,1'-biphenyl)-4-ylsulfonyl)-N-((R)-phenyl(2-pyridinyl)methyl)-1,3-thiazolidine-2-carboxamide; AS 604872

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133

Experts

1.	Aoki, Tomohiro: 1 article (01/2014)
2.	Fukuda, Miyuki: 1 article (01/2014)
3.	Kataoka, Hiroharu: 1 article (01/2014)
4.	Maekawa, Akiko: 1 article (01/2014)
5.	Manabe, Toshiaki: 1 article (01/2014)
6.	Miyamoto, Susumu: 1 article (01/2014)
7.	Narumiya, Shuh: 1 article (01/2014)
8.	Shirakawa, Takayuki: 1 article (01/2014)
9.	Takagi, Yasushi: 1 article (01/2014)
10.	Chollet, André: 1 article (06/2007)

Related Diseases

1.	Premature Birth (Birth, Premature) 06/01/2007 - "In pregnant mice, AS604872 delayed the preterm birth caused by RU486 administration. " 06/01/2007 - "We tested AS604872 for its ability to delay preterm birth in a mouse model in which the anti-progestin agent RU486 triggered parturition. "
2.	Vascular Diseases (Vascular Disease) 01/01/2014 - "These results demonstrate that both IA and aortic dissection are caused by chronic inflammation of the arterial wall, which is worsened by AS604872, cautioning that other FP antagonists may share such deleterious actions in vascular homeostasis and suggesting that AS604872 can be used to make models of these vascular diseases with extensive degeneration. "
3.	Pulmonary Fibrosis (Fibrosing Alveolitis) 01/01/2014 - "Given the involvement of prostaglandin F2α and its receptor, FP, in extracellular matrix remodeling in a mouse model of pulmonary fibrosis, here we induced hypertension and IA in rats by salt loading and hemi-lateral ligation of renal and carotid arteries and examined effects of a selective FP antagonist, AS604872, on these vascular events. "
4.	Inflammation (Inflammations) 01/01/2014 - "Thus, AS604872 exacerbates vascular inflammation in hypertensive rats and facilitates IA and aortic dissection. " 01/01/2014 - "These results demonstrate that both IA and aortic dissection are caused by chronic inflammation of the arterial wall, which is worsened by AS604872, cautioning that other FP antagonists may share such deleterious actions in vascular homeostasis and suggesting that AS604872 can be used to make models of these vascular diseases with extensive degeneration. "
5.	Hypertension (High Blood Pressure) 01/01/2014 - "Given the involvement of prostaglandin F2α and its receptor, FP, in extracellular matrix remodeling in a mouse model of pulmonary fibrosis, here we induced hypertension and IA in rats by salt loading and hemi-lateral ligation of renal and carotid arteries and examined effects of a selective FP antagonist, AS604872, on these vascular events. "

Related Drugs and Biologics

1.	Mifepristone (RU 486)
2.	Salts
3.	Prostaglandins
4.	Progestins (Progestagens)

Related Therapies and Procedures

1.	Ligation