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tubocapsanolide A

withanolide Tubocapsanolide A inhibits proliferation of human lung cancer cells structure in first source

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Fused-Ring Compounds
  - Steroids: 70059
    - Cholestanes
      - Cholestenes
        Ergosterol: 305
        tubocapsanolide A: 4

Experts

1.	Chang, Hui-Chiu: 2 articles (01/2009 - 05/2007)
2.	Hung, Wen-Chun: 2 articles (01/2009 - 05/2007)
3.	Pan, Mei-Ren: 2 articles (01/2009 - 05/2007)
4.	Wu, Yang-Chang: 2 articles (01/2009 - 05/2007)
5.	Chen, Chen: 1 article (01/2021)
6.	Chen, Li-Xia: 1 article (01/2021)
7.	Gong, Lijie: 1 article (01/2021)
8.	Kong, Lingyi: 1 article (01/2021)
9.	Li, Chen: 1 article (01/2021)
10.	Li, Hua: 1 article (01/2021)

Related Diseases

1.	Triple Negative Breast Neoplasms 01/01/2021 - "These findings show that tubocapsanolide A may be a promising molecule for triple-negative breast cancer treatment and merit further evaluation."
2.	Neoplasms (Cancer) 05/01/2007 - "Collectively, we have identified Skp2 as a molecular target for Tubocapsanolide A and suggest that this withanolide may be useful for the prevention or treatment of cancer cells with Skp2 overexpression."
3.	Lung Neoplasms (Lung Cancer) 05/01/2007 - "In addition, we showed that inhibition of Skp2 is a critical step for the suppression of cell proliferation by Tubocapsanolide A because ectoexpression of Skp2 effectively reversed Tubocapsanolide A-induced p27 up-regulation and growth inhibition in human lung cancer cells. " 05/01/2007 - "Tubocapsanolide A inhibited proliferation of A549, H358, and H226 human lung cancer cells via induction of G(1) growth arrest. " 05/01/2007 - "A bioactive withanolide Tubocapsanolide A inhibits proliferation of human lung cancer cells via repressing Skp2 expression."
4.	Colitis 01/01/2021 - "Identification of Tubocapsanolide A as a novel NLRP3 inhibitor for potential treatment of colitis." 01/01/2021 - "Here, we first reported that Tubocapsanolide A (TA), a natural small molecule, as a novel inhibitor of NLRP3 inflammasome for the treatment of colitis. "
5.	Breast Neoplasms (Breast Cancer) 01/30/2009 - "A bioactive withanolide tubocapsanolide A (Tubo A) suppressed NF-kappaB-mediated CCR7 expression in breast cancer cells and attenuated their migration toward lymphatic endothelial cells. "

Related Drugs and Biologics

1.	Inflammasomes
2.	NF-kappa B (NF-kB)