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NK314

a benzo[c]phenanthridine that inhibits topoisomerase IIalpha and G2 cell cycle arrest; structure in first source

Networked: 7 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Phenanthrenes: 27
        NK314: 7
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Phenanthrenes: 27
    - NK314: 7

Experts

1.	Nishikawa, Kiyohiro: 4 articles (08/2011 - 05/2007)
2.	Kopa, Paulina: 2 articles (01/2020 - 08/2019)
3.	Macieja, Anna: 2 articles (01/2020 - 08/2019)
4.	Poplawski, Tomasz: 2 articles (01/2020 - 08/2019)
5.	Guo, Lei: 2 articles (08/2011 - 05/2007)
6.	Liu, Xiaojun: 2 articles (08/2011 - 05/2007)
7.	Plunkett, William: 2 articles (08/2011 - 05/2007)
8.	Okamoto, Kazuya: 2 articles (03/2011 - 01/2008)
9.	Kagaya, Shigehide: 2 articles (08/2008 - 01/2008)
10.	Toyoda, Eriko: 2 articles (08/2008 - 01/2008)

Related Diseases

1.	Glioma (Gliomas) 01/01/2020 - "In this work we investigated the effect of two Top2 inhibitors NK314 and VP-16 in glioma cell lines (MO59 K and MO59 J) sensitized by DNA-PK inhibitor, NU7441. " 08/01/2019 - "We observed a concentration-dependent change in DSB levels and accumulation at the G2/M checkpoint and S-phase in glioma cells incubated with NK314/cisplatin and etoposide/cisplatin. "
2.	Glioblastoma (Glioblastoma Multiforme) 01/01/2020 - "Cytotoxic effect of VP-16, NK314 alone and in combination on human glioblastoma cell lines, was assessed by a colorimetric assay. " 01/01/2020 - "Inhibition of DNA-PK potentiates the synergistic effect of NK314 and etoposide combination on human glioblastoma cells." 08/01/2019 - "In this work, we investigated the effect of three Topo2 inhibitors-etoposide, NK314, or HU-331 in combination with cisplatin in the U-87 human glioblastoma cell line. "
3.	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 05/01/2007 - "The Chk1-Cdc25C-Cdk1 G(2) checkpoint pathway was activated in response to 100 nmol/L NK314 in ML-1 human acute myeloid leukemia cells. "
4.	Adult T-Cell Leukemia-Lymphoma (Leukemia Lymphoma, T Cell, Acute, HTLV I Associated) 03/31/2011 - "NK314 potentiates antitumor activity with adult T-cell leukemia-lymphoma cells by inhibition of dual targets on topoisomerase II{alpha} and DNA-dependent protein kinase."
5.	Neoplasms (Cancer) 01/18/2008 - "As a result of this unique mechanism of DNA breakage, NK314 showed substantial growth inhibition of topoisomerase II inhibitor-resistant tumors." 01/18/2008 - "NK314, a novel topoisomerase II inhibitor, induces rapid DNA double-strand breaks and exhibits superior antitumor effects against tumors resistant to other topoisomerase II inhibitors."

Related Drugs and Biologics

1.	DNA-Activated Protein Kinase
2.	Etoposide (VP 16)
3.	DNA (Deoxyribonucleic Acid)
4.	Topoisomerase II Inhibitors
5.	Type II DNA Topoisomerases (Topoisomerase II)
6.	Cisplatin (Platino)
7.	8- dibenzothiophen- 4- yl- 2- morpholin- 4- yl- chromen- 4- one
8.	cannabidiol hydroxyquinone (HU331)
9.	1,2- di- (4- sulfamidophenyl)- 4- butylpyrazolidine- 3,5- dione (DSB)