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AI-850

a microparticle hydrophobic drug delivery system for paclitaxel

Networked: 2 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Diterpenes: 1470
      - Taxoids: 2650
        Paclitaxel: 22016
        AI-850: 2
  - Cyclic Hydrocarbons: 97
    - Alicyclic Hydrocarbons: 1
      - Cycloparaffins: 6
        Cyclodecanes
        Taxoids: 2650
        Paclitaxel: 22016
        AI-850: 2

Experts

1.	Beeram, Muralidhar: 1 article (06/2007)
2.	Hammond, Susan: 1 article (06/2007)
3.	Lewis, Lionel D: 1 article (06/2007)
4.	MacKay, Kathleen: 1 article (06/2007)
5.	Mita, Alain C: 1 article (06/2007)
6.	Mita, Monica M: 1 article (06/2007)
7.	Olszanski, Anthony J: 1 article (06/2007)
8.	Perez, Raymond P: 1 article (06/2007)
9.	Rowinsky, Eric K: 1 article (06/2007)
10.	Simmons, Cecilia: 1 article (06/2007)

Related Diseases

1.	Neoplasms (Cancer) 06/01/2007 - "This was an open-label phase I dose escalation study of AI-850 in patients with advanced solid malignancies. " 03/01/2005 - "Nude mice implanted with mammary tumors showed improved tolerance of AI-850, enabling higher administrable does of paclitaxel, which resulted in improved efficacy as compared to Taxol administered at its maximum tolerated dose (MTD). " 03/01/2005 - "AI-850, administered as an intravenous injection, has been shown to have improved tolerance in rats and mice and improved efficacy in a tumor model in mice when compared to Taxol." 03/01/2005 - "AI-850 was compared to Taxol following intravenous administration in a rat pharmacokinetic study, a rat tissue distribution study, and a human xenograft mammary tumor (MDA-MB-435) model in nude mice. "
2.	Neutropenia 06/01/2007 - "Grade 4 neutropenia, either exceeding 5 days or complicated by fever, was dose limiting in two of six patients at 250 mg/m(2) AI-850. "
3.	Fever (Fevers) 06/01/2007 - "Grade 4 neutropenia, either exceeding 5 days or complicated by fever, was dose limiting in two of six patients at 250 mg/m(2) AI-850. "

Related Drugs and Biologics

1.	Paclitaxel (Taxol)

Related Therapies and Procedures

1.	Intravenous Injections
2.	Intravenous Administration