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(4-sulfamoylphenylethyl)thioureido fluorescein

structure in first source

Also Known As:

4-SPTU F cpd

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Alterio, Vincenzo: 1 article (06/2006)
2.	Cecchi, Alessandro: 1 article (06/2006)
3.	De Simone, Giuseppina: 1 article (06/2006)
4.	Monti, Simona Maria: 1 article (06/2006)
5.	Pedone, Carlo: 1 article (06/2006)
6.	Scozzafava, Andrea: 1 article (06/2006)
7.	Supuran, Claudiu T: 1 article (06/2006)
8.	Vitale, Rosa Maria: 1 article (06/2006)

Related Diseases

1.

Neoplasms (Cancer)

06/28/2006 - "The X-ray crystal structure of the fluorescent antitumor sulfonamide carbonic anhydrase (CA, EC, 4.2.1.1) inhibitor (4-sulfamoylphenylethyl)thioureido fluorescein (1) in complex with the cytosolic isoform hCA II is reported, together with a modeling study of the adduct of 1 with the tumor-associated isoform hCA IX. Its binding to hCA II is similar to that of other benzesulfonamides, with the ionized sulfonamide coordinated to the Zn2+ ion within the enzyme active site, and also participating in a network of hydrogen bonds with residues Thr199 and Glu106. "

Related Drugs and Biologics

1.	Protein Isoforms (Isoforms)
2.	Sulfonamides
3.	Enzymes
4.	Carbonic Anhydrases (Carbonic Anhydrase)