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N- (7- hydroxy- 5,6,7,8- tetrahydronaphthalen- 1- yl)- 3- (2- (piperidin- 1- yl)- 6- (trifluoromethyl)pyridin- 3- yl)acrylamide

AMG0347 is the (E)-isomer; a TRPV1 antagonist; structure in first source

Also Known As:

AMG 0347; AMG-0347; AMG0347

Networked: 2 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amides: 2428
  - Acrylamides: 12
    - N-(7-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl)-3-(2-(piperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)acrylamide: 2
- Carboxylic Acids: 973
  - Acyclic Acids
    - Acrylates: 212
      - Acrylamides: 12
        N-(7-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl)-3-(2-(piperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)acrylamide: 2
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - N-(7-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl)-3-(2-(piperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)acrylamide: 2

Experts

1.	Gavva, Narender R: 2 articles (06/2008 - 07/2007)
2.	Brennan, Timothy J: 1 article (06/2008)
3.	Wu, Chaoran: 1 article (06/2008)
4.	Almeida, Maria C: 1 article (07/2007)
5.	Bannon, Anthony W: 1 article (07/2007)
6.	Burmeister, Jeffrey J: 1 article (07/2007)
7.	Louis, Jean-Claude: 1 article (07/2007)
8.	Norman, Mark H: 1 article (07/2007)
9.	Oliveira, Daniela L: 1 article (07/2007)
10.	Roberts, Jennifer L: 1 article (07/2007)

Related Diseases

1.	Hyperthermia 07/11/2007 - "AMG0347 was no more effective in causing hyperthermia when administered into the brain (intracerebroventricularly) or spinal cord (intrathecally) than when given systemically (intravenously), which indicates a peripheral site of action. " 07/11/2007 - "The magnitude of the hyperthermic response depended on neither T(b) nor tail-skin temperature at the time of AMG0347 administration, thus indicating that AMG0347-induced hyperthermia results from blockade of tonic TRPV1 activation by nonthermal factors. "
2.	Pain (Aches) 06/01/2008 - "For incisional pain, AMG0347 did not change the withdrawal threshold to mechanical stimulation or the guarding pain score. " 06/01/2008 - "The current study examined the analgesic effects of a recently developed transient receptor potential vanilloid 1 (TRPV1) antagonist, AMG0347, on incisional pain in rats. " 06/01/2008 - "The effect of either AMG0347 or morphine was tested for its effects on guarding pain score, heat withdrawal latency, and mechanical withdrawal threshold. " 06/01/2008 - "Effect of AMG0347, a transient receptor potential type V1 receptor antagonist, and morphine on pain behavior after plantar incision."
3.	Hyperalgesia 06/01/2008 - "AMG0347 only decreased heat hyperalgesia after plantar incision even though both peripheral and central TRPV1 receptors were blocked. " 06/01/2008 - "AMG0347 decreased capsaicin-induced heat and mechanical hyperalgesia and blocked central TRPV1 receptors. "

Related Drugs and Biologics

1.	Analgesics (Analgesic Drugs)
2.	Vasopressin Receptors (Arginine Vasopressin Receptor)
3.	Morphine (MS Contin)
4.	Capsaicin (Zostrix)