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VUF 6002

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a histamine H4 receptor antagonist with antinociceptive and antiinflammatory activities; structure in first source

Also Known As:

VUF-6002; VUF6002

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 60
- 1-Ring Heterocyclic Compounds
  - Piperazines: 18
    - VUF 6002: 1
- 2-Ring Heterocyclic Compounds
  - Benzimidazoles: 111
    - VUF 6002: 1

Experts

1.	Leurs, Rob: 1 article (06/2007)
2.	Adami, Maristella: 1 article (06/2007)
3.	de Esch, Iwan J P: 1 article (06/2007)
4.	Coruzzi, Gabriella: 1 article (06/2007)
5.	Guaita, Elena: 1 article (06/2007)

Related Diseases

1.	Inflammation 06/01/2007 - "Antiinflammatory and antinociceptive effects of the selective histamine H4-receptor antagonists JNJ7777120 and VUF6002 in a rat model of carrageenan-induced acute inflammation." 06/01/2007 - "JNJ7777120 (10 and 30 mg/kg, s.c.) and VUF6002 (10 mg/kg, s.c.) significantly reduced paw edema and hyperalgesia provoked by subplantar injection of carrageenan; the effect was evident against the early (2 h) phase of inflammation. " 06/01/2007 - "The effects of the highly selective histamine H4 receptor antagonists JNJ7777120 and VUF6002 were investigated on the carrageenan-induced inflammation and thermal hyperalgesia in rats. "
2.	Hyperalgesia 06/01/2007 - "JNJ7777120 (10 and 30 mg/kg, s.c.) and VUF6002 (10 mg/kg, s.c.) significantly reduced paw edema and hyperalgesia provoked by subplantar injection of carrageenan; the effect was evident against the early (2 h) phase of inflammation. " 06/01/2007 - "The effects of the highly selective histamine H4 receptor antagonists JNJ7777120 and VUF6002 were investigated on the carrageenan-induced inflammation and thermal hyperalgesia in rats. "
3.	Edema 06/01/2007 - "An inactive analog of VUF6002, VUF6007 (10 mg/kg, s.c.) slightly aggravated paw edema, while leaving unaltered carrageenan-induced nociception. " 06/01/2007 - "JNJ7777120 (10 and 30 mg/kg, s.c.) and VUF6002 (10 mg/kg, s.c.) significantly reduced paw edema and hyperalgesia provoked by subplantar injection of carrageenan; the effect was evident against the early (2 h) phase of inflammation. "

Related Drugs and Biologics

1.	Histamine (Histamine Dihydrochloride)
2.	Carrageenan