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N- (1- ((6- fluoro- 2- naphthyl)methyl)pyrrolidin- 3- yl)- 2- (1- ((6- methylpyridazin- 3- yl)carbonyl)piperidin- 4- ylidene)acetamide

YM-344484 is the (3R)-isomer; both a histamine H1 receptor antagonist and a CCR3 receptor antagonist; structure in first source

Also Known As:

YM 344484; YM-344484; YM344484

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperidines: 17
    - N-(1-((6-fluoro-2-naphthyl)methyl)pyrrolidin-3-yl)-2-(1-((6-methylpyridazin-3-yl)carbonyl)piperidin-4-ylidene)acetamide: 1
  - Pyridazines: 11
    - N-(1-((6-fluoro-2-naphthyl)methyl)pyrrolidin-3-yl)-2-(1-((6-methylpyridazin-3-yl)carbonyl)piperidin-4-ylidene)acetamide: 1

Experts

1.	Kaneko, Masayuki: 1 article (06/2007)
2.	Morihira, Koichiro: 1 article (06/2007)
3.	Morokata, Tatsuaki: 1 article (06/2007)
4.	Sato, Ippei: 1 article (06/2007)
5.	Shimizu, Yasuaki: 1 article (06/2007)
6.	Suzuki, Keiko: 1 article (06/2007)
7.	Takahashi, Koichiro: 1 article (06/2007)
8.	Takizawa, Satoko: 1 article (06/2007)

Related Diseases

1.	Inflammation (Inflammations) 06/01/2007 - "These results indicate that YM-344484, a novel and functional dual antagonist for chemokine CCR3 receptor and histamine H1 receptor, is an attractive candidate for development as a novel anti-allergic inflammation drug."
2.	Asthma (Bronchial Asthma) 06/01/2007 - "Orally administered YM-344484 inhibited the increase in histamine-induced vascular permeability in mice (82% inhibition at a dose of 10 mg/kg) and the accumulation of eosinophils in a mouse asthma model (74% at a dose of 300 mg/kg). "

Related Drugs and Biologics

1.	CCR3 Receptors
2.	Anti-Allergic Agents (Antiallergic Agents)
3.	Chemokines
4.	Histamine H1 Receptors (Histamine H1 Receptor)
5.	Histamine (Histamine Dihydrochloride)