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1- (methanesulfonamido- 1- naphthyloxy)- 2- (N- (4- methane sulfonamidophenethyl)-N-acetamido)ethane

potential anti-arrhythmia agent; structure in first source

Also Known As:

CPU228

Networked: 2 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Naphthalenes: 18
    - 1-(methanesulfonamido-1-naphthyloxy)-2-(N-(4-methane sulfonamidophenethyl)-N-acetamido)ethane: 2

Experts

1.	Dai, De-Zai: 2 articles (01/2010 - 04/2007)
2.	Dai, Yin: 2 articles (01/2010 - 04/2007)
3.	Hamed, Khan Hussien: 1 article (01/2010)
4.	Hu, Chen: 1 article (01/2010)
5.	Yu, Feng: 1 article (01/2010)
6.	Huang, Zhi-Jiang: 1 article (04/2007)
7.	Ji, Min: 1 article (04/2007)
8.	Li, Na: 1 article (04/2007)
9.	Na, Tao: 1 article (04/2007)

Related Diseases

1.	Heart Failure 01/01/2010 - "CPU228 was more effective than dofetilide in attenuating heart failure by normalizing isoproterenol-induced changes, including downregulation of FKBP12.6, upregulation of NADPH oxidase and PKC epsilon hyperphosphorylation in vivo and in vitro." 01/01/2010 - "The aim of this study was to determine if CPU228, a derivative of dofetilide, is more effective than dofetilide in attenuating isoproterenol-induced heart failure by recovering downregulated FK506 binding protein (FKBP12.6), and suppressing oxidative stress, upregulated NADPH oxidase and protein kinase C epsilon (PKC epsilon) hyperphosphorylation in the myocardium. "
2.	Torsades de Pointes (Torsade de Pointes) 04/01/2007 - "Calcium antagonist property of CPU228, a dofetilide derivative, contributes to its low incidence of torsades de pointes in rabbits."

Related Drugs and Biologics

1.	dofetilide (Tikosyn)
2.	Protein Kinase C-epsilon
3.	Tacrolimus Binding Proteins (FKBP)
4.	NADPH Oxidases (NAD(P)H oxidase)
5.	Isoproterenol (Isoprenaline)
6.	tacrolimus binding protein 1B
7.	Calcium