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5- (6'- triphenylphosphoniumhexyl)- 5,6- dihydro- 6- phenyl- 3,8- phenanthridinediammine

Also Known As:
MitoSOX
Networked: 43 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Chang, Hsueh-Wei: 3 articles (07/2021 - 09/2019)
2. Tang, Jen-Yang: 3 articles (07/2021 - 09/2019)
3. Baudrimont, Isabelle: 2 articles (04/2022 - 01/2022)
4. Baudrimont, Magalie: 2 articles (04/2022 - 01/2022)
5. Deweirdt, Juliette: 2 articles (04/2022 - 01/2022)
6. Ducret, Thomas: 2 articles (04/2022 - 01/2022)
7. Errera, Marie-Hélène: 2 articles (04/2022 - 01/2022)
8. Freund-Michel, Véronique: 2 articles (04/2022 - 01/2022)
9. Germande, Ophélie: 2 articles (04/2022 - 01/2022)
10. Guibert, Christelle: 2 articles (04/2022 - 01/2022)

Related Diseases

1. Hypoxia (Hypoxemia)
2. Mitochondrial Diseases (Mitochondrial Disease)
03/07/2022 - "DPCs were used to investigate the effect of DHT on mitochondrial dysfunction with MitoSOX and Rhod-2 staining. "
01/01/2020 - "We found that ALDH2 deficiency resulted in partial mitochondrial dysfunction in gastrocnemius muscle because it increased mitochondrial reactive oxygen species (ROS) emission (2',7'-dichlorofluorescein and MitoSOX oxidation rate during respiration) and the frequency of regional mitochondrial depolarization. "
09/01/2015 - "Collectively, our results suggest that the matrix accumulation of MitoSOX or dihydroethidium oxidation products causes mitochondrial uncoupling and inhibition of complex IV. Because MitoSOX is inherently capable of causing severe mitochondrial dysfunction with the potential to alter superoxide production, its use therefore requires careful optimization in imaging protocols. "
01/01/2022 - "The following different endpoints were studied: (i) ROS production using CM-H2DCF-DA probe, electron spin resonance, and MitoSOX probe; the SOD activity was also measured (ii) calcium signaling with Fluo4-AM, Rhod-2, and Fluo4-FF probes; (iii) inflammation by IL-6 production and secretion and, (iv) mitochondrial dysfunction and apoptosis with TMRM and MitoTracker probes, and AnnexinV/PI. "
04/26/2022 - "The following endpoints were studied: (i) ROS production using CM-H2DCF-DA and MitoSOX probes, (ii) nitrite production by the Griess reaction, (iii) IL-6 secretion by ELISA, (iv) calcium signaling with a Fluo-4 AM probe, and (v) mitochondrial dysfunction with TMRM and MitoTracker probes. "
3. Mouth Neoplasms (Oral Cancer)
4. Inflammation (Inflammations)
01/01/2022 - "The following different endpoints were studied: (i) ROS production using CM-H2DCF-DA probe, electron spin resonance, and MitoSOX probe; the SOD activity was also measured (ii) calcium signaling with Fluo4-AM, Rhod-2, and Fluo4-FF probes; (iii) inflammation by IL-6 production and secretion and, (iv) mitochondrial dysfunction and apoptosis with TMRM and MitoTracker probes, and AnnexinV/PI. "
01/01/2019 - "Results:In vitro treatment with NC remarkably protected macrophages from lipopolysaccharide-induced inflammation and oxidative stress as evident from the results of 2',7'-dichlorofluorescin diacetate, JC-1 and MitoSox staining. "
08/01/2013 - "By using the mitochondrial-specific superoxide dye MitoSox and complex I inhibitor rotenone, we identified the mitochondrial respiratory chain as the major PGC-1α-dependent reactive oxygen species source in vivo, accompanied by increased vascular inflammation and cell senescence. "
01/01/2020 - "In vitro results showed the protein expressions of inflammation (IL-1β/TNF-α/IL-6), apoptosis (mitochondrial-Bax/cleaved-caspase-3/cleaved-PARP) and autophagy (beclin/Atg5/LC3B-II to LC3B-I ratio) as well as protein (NOX-1/NOX-2/p22phox/oxidized-protein), total cellular (H2DCFDA) and mitochondrial (Mitosox) levels of oxidative stress were significantly increased in p-Cresol-treated umbilical vein endothelial cells (HUVECs) as compared with control, whereas angiogenesis capacity (i.e., Matrigel-assay for HUVECs) exhibited an opposite pattern to inflammation between the two groups (all P < 0.001). "
5. Neoplasms (Cancer)

Related Drugs and Biologics

1. Superoxides (Superoxide)
2. Reactive Oxygen Species (Oxygen Radicals)
3. Proteins (Proteins, Gene)
4. Coloring Agents (Dyes)
5. Matrix Metalloproteinases (MMPs)
6. diacetyldichlorofluorescein
7. Small Interfering RNA (siRNA)
8. Interleukin-6 (Interleukin 6)
9. Metformin (Glucophage)
10. Antioxidants