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N'- (10H- indolo(3,2- b)quinolin- 11- yl)- N,N- dimethylpropane- 1,3- diamine

a G-quadruplex-interacting agent that can inhibit c-myc gene promoter and telomerase activity

Also Known As:

SYUIQ-5

Networked: 4 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Polyamines: 3918
    - Diamines: 518
      - N'-(10H-indolo(3,2-b)quinolin-11-yl)-N,N-dimethylpropane-1,3-diamine: 4
Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinolines: 146
      - N'-(10H-indolo(3,2-b)quinolin-11-yl)-N,N-dimethylpropane-1,3-diamine: 4

Experts

1.	Deng, Rong: 2 articles (12/2009 - 10/2009)
2.	Feng, Gong-Kan: 2 articles (12/2009 - 10/2009)
3.	Gu, Lian-Quan: 2 articles (12/2009 - 07/2007)
4.	Zhou, Wen-Jun: 2 articles (12/2009 - 10/2009)
5.	Zhu, Xiao-Feng: 2 articles (12/2009 - 10/2009)
6.	Zhang, Xiao-Yue: 1 article (12/2009)
7.	Chen, Xiao: 1 article (07/2007)
8.	Chowbay, Balram: 1 article (07/2007)
9.	Guan, Su: 1 article (07/2007)
10.	He, Fan: 1 article (07/2007)

Related Diseases

1.	Neoplasms (Cancer) 12/01/2009 - "In this study, we showed that SYUIQ-5 inhibited proliferation of CNE2 and HeLa cancer cells, triggered a rapid and potent telomere DNA damage response characterized by the formation of telomeric foci gamma-H2AX, and obviously induced autophagy with the features of increased LC3-II and a punctuated pattern of YFP-LC3 fluorescence. " 12/01/2009 - "These results indicated that SYUIQ-5 triggered potent telomere damage through TRF2 delocalization from telomeres, and eventually induced autophagic cell death in cancer cells. " 10/01/2009 - "SYUIQ-5 induces autophagy in cancer cells. " 12/01/2009 - "G-quadruplex ligand SYUIQ-5 induces autophagy by telomere damage and TRF2 delocalization in cancer cells." 07/01/2007 - "A sensitive assay for the determination of SYUIQ-5, a novel telomerase inhibitor and anti-tumor drug, in rat liver microsomes was developed by using high-performance liquid chromatography with ultraviolet detection. "
2.	Nasopharyngeal Neoplasms (Cancer of the Nasopharynx) 10/01/2009 - "This study was to investigate autophagy induced by a G-quadruplex ligand SYUIQ-5 and its mechanisms in nasopharyngeal cancer cells. " 10/01/2009 - "[A G-quadruplex ligand SYUIQ-5 induces autophagy by inhibiting the Akt-FOXO3a pathway in nasopharyngeal cancer cells]."
3.	Leukemia 06/01/2007 - "Inhibition of myc promoter and telomerase activity and induction of delayed apoptosis by SYUIQ-5, a novel G-quadruplex interactive agent in leukemia cells."

Related Drugs and Biologics

1.	Telomerase (Telomerase Reverse Transcriptase)
2.	Ligands
3.	Enzymes

Related Therapies and Procedures

1.	Therapeutics