(2- (4- (2- benzimidazol- 2ylthio)ethyl)piperazin- 1yl)- N- (2,4- bis(methylthio)- 6- methyl- 3- pyridyl)acetamide

a selective ACAT-1 inhibitor that suppresses fatty streak lesions in fat-fed hamsters without affecting plasma cholesterol levels; structure in first source

Also Known As:

2-(4-(2-(benzimidazol-2- ylthio)ethyl)piperazin-1-yl)-N-(2,4- bis(methylthio)-6-methyl-3-pyridyl)acetamide; 2-(4-(2-(benzimidazol-2-ylthio)ethyl)piperazin-1-yl)-N-(2,4-bis(methylthio)-6-methyl-3-pyridyl)acetamide; K-604; K604 compound

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzimidazoles: 245
      - (2-(4-(2-benzimidazol-2ylthio)ethyl)piperazin-1yl)-N-(2,4-bis(methylthio)-6-methyl-3-pyridyl)acetamide: 5

Experts

1.	Shibuya, Kimiyuki: 3 articles (10/2019 - 04/2007)
2.	Kobayashi, Hideyuki: 2 articles (11/2010 - 04/2007)
3.	Miyazaki, Akira: 2 articles (11/2010 - 04/2007)
4.	Watanabe, Takuya: 2 articles (11/2010 - 04/2007)
5.	Yoshinaka, Yasunobu: 2 articles (11/2010 - 04/2007)
6.	Miyamoto, Masayoshi: 1 article (10/2019)
7.	Morikawa, Shigeru: 1 article (10/2019)
8.	Noguchi, Noriko: 1 article (10/2019)
9.	Ogawa, Shin-Ichiro: 1 article (10/2019)
10.	Tsunenari, Yoshihiko: 1 article (10/2019)

Related Diseases

1.	Atherosclerotic Plaque (Atheroma) 11/01/2010 - "Administration of K-604 to 8-week-old apoE-knockout mice for 12 weeks at a dose of 60 mg/kg/day significantly reduced macrophage-positive area and increased collagen-positive area in atherosclerotic plaques in the aorta without affecting plasma cholesterol levels or lesion areas, indicating direct plaque-modulating effects of K-604 on vascular walls independent of plasma cholesterol levels. "
2.	Lung Injury 01/01/2022 - "Intratracheal Administration of Acyl Coenzyme A Acyltransferase-1 Inhibitor K-604 Reduces Pulmonary Inflammation Following Bleomycin-Induced Lung Injury."
3.	Atherosclerosis 04/01/2007 - "K-604, a potent and selective inhibitor of ACAT-1, suppressed the development of atherosclerosis in an animal model without affecting plasma cholesterol levels, providing direct evidence that pharmacological inhibition of ACAT-1 in the arterial walls leads to suppression of atherosclerosis."
4.	Pneumonia (Pneumonitis) 01/01/2022 - "Intratracheal Administration of Acyl Coenzyme A Acyltransferase-1 Inhibitor K-604 Reduces Pulmonary Inflammation Following Bleomycin-Induced Lung Injury."
5.	Inflammation (Inflammations) 01/01/2022 - "Intratracheal administration of K-604, an Acat-1 inhibitor, reduces intracellular cholesterol ester accumulation in lung macrophages, attenuates inflammation and macrophage activation, and normalizes mediators of surface-active function after intratracheal bleomycin administration in a rodent model. "

Related Drugs and Biologics

1.	Cholesterol
2.	Acyl Coenzyme A (Acyl CoA)
3.	Collagen
4.	Cholesterol Esters (Cholesteryl Esters)
5.	Bleomycin (Blenoxane)