meta-((211)At)astatobenzylguanidine

01/01/2022 - "[211At]MABG has significant survival advantage in disseminated models of neuroblastoma. "
01/01/2022 - "Here we investigated the safety and antitumor activity [211At]MABG in preclinical models of neuroblastoma. "
01/01/2022 - "Finally, we explored the efficacy of [211At]MABG after tail vein xenografting designed to model disseminated neuroblastoma. "
08/01/1996 - "A paired-label biodistribution was performed in athymic mice bearing SK-N-SH human neuroblastoma xenografts to compare the tissue uptake of meta-[211At]astatobenzylguanidine ([211At]MABG) and [131I]MIBG. "
10/15/1994 - "In conclusion, these results have demonstrated that [211At]MABG is considerably more cytotoxic than [131I]MIBG and that [211At]MABG could have great potential as a radiotherapeutic agent for the treatment of neuroblastoma."

11/01/2005 - "We conclude that NAT gene transfer combined with the administration of n.c.a.[131I]MIBG or [211At]MABG, is a promising novel treatment approach for bladder cancer therapy."

09/01/2022 - "In contrast, there was an increasing trend of [211At]MABG uptake in the PC-12 tumors. "
08/01/1996 - "These results suggest such strategies might be useful for improving [211At]MABG tumor-to-normal tissue ratios."
08/01/1996 - "Pretreatment of mice with unlabeled MIBG increased tumor uptake of [211At]MABG by 1.5-fold while reducing uptake in heart and several other normal tissues. "
08/01/1996 - "Desipramine reduced tumor uptake of [211At] MABG by 43%, suggesting that its accumulation was related to the specific uptake-1 mechanism. "
08/01/1996 - "Significantly higher (p < 0.05) uptake of [211At]MABG was seen in tumor (3.8 +/- 0.8% ID/g vs. 3.1 +/- 0.7% ID/g at 8 h) compared to [131I]MIBG. "

09/01/2022 - "Meta-[211At]astato-benzylguanidine ([211At]MABG) accumulates in pheochromocytoma via norepinephrine transporter (NET) and leads to a strong antitumor effect, but it also distributed in normal tissues non-specifically. "

09/01/2022 - "[123I]MIBG and [211At]MABG uptake was investigated in PC-12 (rat pheochromocytoma cell line), NIH/3T3 (mouse fibroblasts cell line), ACHN (human renal cancer cell line), and BxPC-3 (human pancreatic cancer cell line). "