berkelic acid

structure in first source

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

1.	Bender, Christopher F: 1 article (03/2018)
2.	De Brabander, Jef K: 1 article (03/2018)
3.	Lynch, Vincent M: 1 article (03/2018)
4.	Paradise, Christopher L: 1 article (03/2018)
5.	Yoshimoto, Francis K: 1 article (03/2018)
6.	Brimble, Margaret A: 1 article (03/2010)
7.	Wilson, Zoe E: 1 article (03/2010)
8.	Kelly, Kal: 1 article (07/2006)
9.	Stierle, Andrea A: 1 article (07/2006)
10.	Stierle, Donald B: 1 article (07/2006)

1.	Ovarian Neoplasms (Ovarian Cancer) 03/21/2010 - "The one-pot Horner-Wadsworth-Emmons/oxa-Michael cascade followed by spiroketalisation affords the tetracyclic benzannulated spiroketal core of berkelic acid, an extremophile natural product with selective activity against ovarian cancer." 07/07/2006 - "Bioassay-guided fractionation using signal transduction enzyme assays led to the isolation of the novel spiroketal, berkelic acid 1, and of the known gamma-pyrone, spiciferone A 4. Berkelic acid has shown selective, nanomolar activity against OVCAR-3, an ovarian cancer cell line in the National Cancer Institute cell line screen. "
2.	Neoplasms (Cancer) 03/01/2018 - "In addition to berkelic acid, C22-epi-berkelic acid, and nor-berkelic acids, we synthesized C26-oxoberkelic acid analogs that were evaluated against human cancer cell lines. "
3.	Dehydration (Water Stress) 03/01/2018 - "After defining optimal parameters, we executed a one-pot silver-mediated in situ dehydration of an isochroman lactol to methyl pulvillorate, the cycloisomerization of a spicifernin-like alkynol to the corresponding exocyclic enol ether, and a subsequent cycloaddition to deliver the tetracyclic core of berkelic acid. "