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1-(2-aminopropyl)-1H-indazole-6-ol
AL-34462 is the (S)-isomer; an antihypertensive agent; structure in first source
Also Known As:
AL 34662; AL-34662; AL34662
Networked:
2
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Azoles: 2138
Pyrazoles: 61
Indazoles: 179
1-(2-aminopropyl)-1H-indazole-6-ol: 2
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Indazoles: 179
1-(2-aminopropyl)-1H-indazole-6-ol: 2
Experts
1.
Sharif, Najam A
: 2 articles (08/2010 - 02/2007)
2.
Kelly, Curtis R
: 1 article (02/2007)
3.
McLaughlin, Marsha A
: 1 article (02/2007)
Related Diseases
1.
Ocular Hypertension (Glaucoma, Suspect)
08/01/2010 - "
As a result of further structure-activity investigations, AL-34662, a selective 5HT(2) agonist (relative to other 5HT receptor types and sub-types) with high affinity, potency and efficacy at 5HT(2A), 5HT(2B) and 5HT(2C) receptors was discovered that efficaciously lowered IOP in the monkey model of ocular hypertension (33 +/- 3 % reduction out to 6 hrs post with a 300 microg topical ocular dose).
"
2.
Hyperemia
02/01/2007 - "
AL-34662 caused relatively minimal ocular discomfort and hyperemia in rabbit and guinea pig eyes.
"
Related Drugs and Biologics
1.
trichostatin A (A 300)