HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

schisandrol A

dibenzocyclooctadiene lignan from Schisandra chinensis; structure in first source

Networked: 12 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Benzyl Compounds: 2
        Lignans: 1113
        schisandrol A: 12
    - Alicyclic Hydrocarbons: 1
      - Cycloparaffins: 6
        Cyclooctanes: 4
        schisandrol A: 12

Experts

1.	Chen, Dongxin: 1 article (05/2022)
2.	Fan, Guorong: 1 article (05/2022)
3.	Huang, Xucong: 1 article (05/2022)
4.	Jia, Mengqi: 1 article (05/2022)
5.	Li, Xiaojing: 1 article (05/2022)
6.	Lou, Yuefen: 1 article (05/2022)
7.	Qian, Feng: 1 article (05/2022)
8.	Qiaolongbatu, Xijier: 1 article (05/2022)
9.	Wu, Jiaqi: 1 article (05/2022)
10.	Wu, Zhenghua: 1 article (05/2022)

Related Diseases

1.	Inflammation (Inflammations) 10/01/2023 - "Schisandrol A alleviated the symptoms of DILI in mice by inhibiting oxidative stress and inflammation, whereas, it alleviated DILI by activating autophagy in the exosomes." 12/01/2019 - "Results showed that schisandrol A may enhance the PI3K/AKT pathway, inhibit the IKK/IκBα/NF-κB pathway, reduce neuronal inflammation and oxidative stress, and enhance the survival of DA neurons in the brain of mice. " 01/01/2022 - "The study demonstrated that Schisandrol A could play critical roles in DILI by APAP via regulating TNF signaling pathway, inhibiting oxidative stress, inflammation and inhibiting the activities of cytochrome P450 enzymes, which contributed to searching for leading compounds and the development of new drugs for DILI by APAP."
2.	Chemical and Drug Induced Liver Injury 10/01/2023 - "Schisandrol A, a bioactive constituent from Schisandrae Chinensis Fructus, alleviates drug-induced liver injury by autophagy activation via exosomes." 01/01/2022 - "Network pharmacology, molecular docking technology integrated with pharmacodynamic study to reveal the potential targets of Schisandrol A in drug-induced liver injury by acetaminophen."
3.	Parkinson Disease (Parkinson's Disease) 04/26/2023 - "Simultaneous and dynamic measurement of Schisandrol A changes in rat blood and brain and its comparative pharmacokinetic study in control and Parkinson's disease rats by dual-probe in vivo microdialysis." 12/01/2019 - "These results indicate that schisandrol A is expected to be a potential drug for improving Parkinson's disease."
4.	Fibrosis (Cirrhosis) 05/10/2022 - "Network pharmacology study and molecular docking analysis indicated that schisandrol A (L1) play an anti-fibrosis role by regulating the TGF-β signaling pathway. " 05/26/2015 - "After oral administration of FZHY at a dose of 15g/kg, the pharmacokinetic behaviors of schizandrin A (SIA), schizandrin B (SIB), schizandrin C (SIC), schisandrol A (SOA), Schisandrol B (SOB) and schisantherin A (STA) have been significantly changed in hepatic fibrosis rats compared with the normal rats, and their AUC(0-t) values were increased by 235.09%, 388.44%, 223.30%, 669.30%, 295.08% and 267.63% orderly (P<0.05). "
5.	Pulmonary Fibrosis (Fibrosing Alveolitis) 01/01/2023 - "The Therapeutic Mechanism of Schisandrol A and Its Metabolites on Pulmonary Fibrosis Based on Plasma Metabonomics and Network Analysis." 05/10/2022 - "The effect and mechanism of schisandrol A inhibiting pulmonary fibrosis were reported for the first time. " 05/10/2022 - "Experimental in vitro and in vivo verified that the schisandrol A could inhibiting pulmonary fibrosis through TGF-β signaling pathway. " 05/10/2022 - "Schisandrol A, the main active ingredient of Schisandrae Chinensis Fructus, inhibits pulmonary fibrosis through suppression of the TGF-β signaling pathway as revealed by UPLC-Q-TOF/MS, network pharmacology and experimental verification."

Related Drugs and Biologics

1.	Enzymes
2.	Cytochrome P-450 Enzyme System (Cytochrome P450)
3.	Acetaminophen (Paracetamol)
4.	schizandrin B
5.	schizandrin A
6.	schizandrer A
7.	schizandrol B
8.	Multidrug Resistance-Associated Proteins
9.	Lignans
10.	Estrogen Receptors

Related Therapies and Procedures

1.	Oral Administration