6- (1- oxobutyl)- 5,8- dimethoxy- 1,4- naphthoquinone

inhibits lewis lung cancer by antiangiogenesis and apoptosis; structure in first source

Also Known As:

DMNQ-S17; OB-DMNQ cpd

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Naphthalenes: 18
        Naphthoquinones: 418
        6-(1-oxobutyl)-5,8-dimethoxy-1,4-naphthoquinone: 3
- Quinones: 434
  - Naphthoquinones: 418
    - 6-(1-oxobutyl)-5,8-dimethoxy-1,4-naphthoquinone: 3
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Naphthalenes: 18
    - Naphthoquinones: 418
      - 6-(1-oxobutyl)-5,8-dimethoxy-1,4-naphthoquinone: 3

Experts

1.	Kim, Sung-Hoon: 2 articles (09/2008 - 06/2007)
2.	Lee, Hyo-Jung: 2 articles (09/2008 - 06/2007)
3.	Ahn, Kwang Seok: 1 article (09/2008)
4.	Ahn, Kyoo-Seok: 1 article (09/2008)
5.	Kim, Cheol-Ho: 1 article (09/2008)
6.	Kim, Myung Ok: 1 article (09/2008)
7.	Kwon, Hee-Young: 1 article (09/2008)
8.	Lee, Eun-Ok: 1 article (09/2008)
9.	Park, Min-Jong: 1 article (09/2008)
10.	Celik, Yusuf: 1 article (05/2008)

Related Diseases

1.	Myeloid Leukemia (Leukemia, Myelocytic) 09/26/2008 - "Thus, to elucidate the apoptotic mechanism of DMNQ-S17, this study was performed in myeloid leukemia U937 cells by 2,3-bis [2-methoxy-4-nitro-5-sulfophenyl]-2H-tetrazolium-5-carboxanilide (XTT) assay, eletrophoretic mobility shift assay (EMSA), terminal deoxynucleotidyl transferase mediated dUTP nick end labeling (TUNEL) assay, 4',6-diamidino-2-phenylindole (DAPI) staining, and Western blotting. " 09/26/2008 - "Taken together, these findings suggest that DMNQ-S17 can be a potent anticancer candidate for myeloid leukemias by the suppression of NF-kappaB activation leading to the activation of caspase-3 in human myeloid leukemia U937 cells." 09/26/2008 - "DMNQ-S17 inhibits constitutive NF-kappaB activation leading to induction of apoptosis through the activation of caspase-3 in human myeloid leukemia U937 cells."
2.	Lung Neoplasms (Lung Cancer) 05/15/2008 - "6-(1-Oxobutyl)-5,8-dimethoxy-1,4-naphthoquinone inhibits Lewis lung cancer by antiangiogenesis and apoptosis." 06/01/2007 - "6-(1-Oxobutyl)-5,8-dimethoxy-1,4-naphthoquinone inhibits lewis lung cancer by antiangiogenesis and apoptosis."
3.	Sarcoma (Soft Tissue Sarcoma) 06/01/2007 - "Previously we have reported that 6-(1-oxobutyl)-5,8-dimethoxy-1,4-naphthoquinone (OXO) exhibits anti-tumor activity against S-180 sarcoma in vitro and in vivo. "
4.	Neoplasms (Cancer) 06/01/2007 - "Previously we have reported that 6-(1-oxobutyl)-5,8-dimethoxy-1,4-naphthoquinone (OXO) exhibits anti-tumor activity against S-180 sarcoma in vitro and in vivo. "

Related Drugs and Biologics

1.	DNA Nucleotidylexotransferase (Terminal Deoxynucleotidyl Transferase)
2.	DAPI
3.	Caspase 3 (Caspase-3)
4.	NF-kappa B (NF-kB)