VER-50589

inhibits heat shock protein 90 molecular chaperone; structure in first source

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

1.	Neoplasms (Cancer) 07/15/2023 - "In tumor cell viability experiment, compound 12-1 robustly repressed the proliferation against six human tumor cells with IC50 values all in nanomolar range scoring over VER-50589 and geldanamycin. " 04/01/2007 - "Mean cellular antiproliferative GI(50) values for VER-50589 and VER-49009 for a human cancer cell line panel were 78 +/- 15 and 685 +/- 119 nmol/L, respectively, showing a 9-fold potency gain for the isoxazole. "
2.	Infections 01/01/2023 - "EV71 infection activated the AKT and ERK signaling pathways, and phosphorylation of AKT and RAF/MEK/ERK was weakened by VER-50589 administration. "
3.	Colonic Neoplasms (Colon Cancer) 04/01/2007 - "VER-50589 accumulated in HCT116 human colon cancer xenografts at levels above the cellular GI(50) for 24 h, resulting in 30% growth inhibition. "
4.	Carcinoma (Carcinomatosis) 04/01/2007 - "Extent and duration of pharmacodynamic changes in an orthotopic human ovarian carcinoma model confirmed the superiority of VER-50589 over VER-49009. "

1.	Mitogen-Activated Protein Kinase Kinases (MEKs)
2.	Isoxazoles
3.	VER-49009
4.	geldanamycin