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AS602868

anilinopyrimidine derivative

Networked: 9 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - AS602868: 9

Experts

1.	Dreano, Michel: 3 articles (07/2011 - 04/2004)
2.	Dumontet, Charles: 2 articles (07/2011 - 01/2011)
3.	Dreano, M: 2 articles (05/2008 - 01/2008)
4.	Cros-Perrial, Emeline: 1 article (07/2011)
5.	Demangel, Delphine: 1 article (07/2011)
6.	Herveau, Stéphanie: 1 article (07/2011)
7.	Jordheim, Lars Petter: 1 article (07/2011)
8.	Keime, Céline: 1 article (07/2011)
9.	Plesa, Adriana: 1 article (07/2011)
10.	Vendrell, Julie A: 1 article (07/2011)

Related Diseases

1.	Inflammation (Inflammations) 05/01/2008 - "Systemic pharmacological IKK2 inhibition by AS602868 treatment efficiently prevented liver steatosis and inflammation, and improved antioxidant response. "
2.	Fatty Liver 05/01/2008 - "Systemic pharmacological IKK2 inhibition by AS602868 treatment efficiently prevented liver steatosis and inflammation, and improved antioxidant response. "
3.	Hemorrhagic Shock 07/01/2005 - "AS602868, a novel chemical inhibitor of IKK2, protected mice from liver injury due to I/R without sensitizing them toward TNF-induced apoptosis and could therefore emerge as a new pharmacological therapy for liver resection, hemorrhagic shock, or transplantation surgery." 04/01/2005 - "AS602868, a novel chemical inhibitor of IKK2, protected mice from liver injury due to I/R without sensitizing them toward TNF-induced apoptosis and could therefore emerge as a new pharmacological therapy for liver resection, hemorrhagic shock, or transplantation surgery."
4.	Disease Progression 04/01/2004 - "These results prompted us to assess the effects of AS602868, a specific small molecule inhibitor of IkappaB kinase 2 (IKK2) on disease progression. "
5.	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 07/01/2011 - "Sensitivity and gene expression profile of fresh human acute myeloid leukemia cells exposed ex vivo to AS602868."

Related Drugs and Biologics

1.	Antioxidants
2.	NF-kappa B (NF-kB)
3.	Topoisomerase I Inhibitors
4.	I-kappa B Kinase
5.	Insulin-Like Growth Factor I (IGF-1)
6.	Irinotecan (Camptosar)

Related Therapies and Procedures

1.	Transplantation
2.	Therapeutics