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1- (1- methylethyl)- 4- ((1- (6- (trifluoromethyl)- 3- pyridinyl)- 4- piperidinyl)carbonyl)hexahydro- 1H- 1,4- diazepine

an H3 receptor antagonist; structure in first source

Also Known As:

GSK 334429; GSK-334429; GSK334429

Networked: 3 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - 1-(1-methylethyl)-4-((1-(6-(trifluoromethyl)-3-pyridinyl)-4-piperidinyl)carbonyl)hexahydro-1H-1,4-diazepine: 3
  - Azepines: 11
    - 1-(1-methylethyl)-4-((1-(6-(trifluoromethyl)-3-pyridinyl)-4-piperidinyl)carbonyl)hexahydro-1H-1,4-diazepine: 3

Experts

1.	Medhurst, Andrew D: 2 articles (08/2008 - 04/2007)
2.	Medhurst, Stephen J: 2 articles (08/2008 - 04/2007)
3.	Kyriakidis, Konstantinos: 1 article (01/2015)
4.	Palaiologou, Marina: 1 article (01/2015)
5.	Tiligada, Ekaterini: 1 article (01/2015)
6.	Tiniakos, Dina: 1 article (01/2015)
7.	Zampeli, Evangelia: 1 article (01/2015)
8.	Billinton, Andy: 1 article (08/2008)
9.	Bingham, Sharon: 1 article (08/2008)
10.	Brass, Amanda: 1 article (08/2008)

Related Diseases

1.	Neuralgia (Stump Neuralgia) 08/15/2008 - "These data suggest that H(3) antagonists such as GSK189254 and GSK334429 may be useful for the treatment of neuropathic pain." 04/15/2007 - "Novel H(3) receptor antagonists such as GSK207040 and GSK334429 may therefore have therapeutic potential not only in dementia but also in neuropathic pain." 08/15/2008 - "In the present study we investigated the effects of the novel potent and highly selective H(3) receptor antagonists GSK189254 (6-[(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]-N-methyl-3-pyridinecarboxamide hydrochloride) and GSK334429 (1-(1-methylethyl)-4-([1-[6-(trifluoromethyl)-3-pyridinyl]-4-piperidinyl]carbonyl)hexahydro-1H-1,4-diazepine) in two rat models of neuropathic pain, namely the chronic constriction injury (CCI) model and the varicella-zoster virus (VZV) model. " 08/15/2008 - "Novel histamine H3 receptor antagonists GSK189254 and GSK334429 are efficacious in surgically-induced and virally-induced rat models of neuropathic pain."
2.	Hyperalgesia 04/15/2007 - "In addition, GSK207040 (0.1, 0.3 and 1mg/kg p.o.) and GSK334429 (3 and 10mg/kg p.o.) significantly reversed capsaicin-induced reductions in paw withdrawal threshold, suggesting for the first time that blockade of H(3) receptors may be able to reduce tactile allodynia. " 04/15/2007 - "Structurally novel histamine H3 receptor antagonists GSK207040 and GSK334429 improve scopolamine-induced memory impairment and capsaicin-induced secondary allodynia in rats."
3.	Dementia (Dementias) 04/15/2007 - "Novel H(3) receptor antagonists such as GSK207040 and GSK334429 may therefore have therapeutic potential not only in dementia but also in neuropathic pain."
4.	Arthritis (Polyarthritis) 01/01/2015 - "In arthritis, prophylactic treatment with GSK334429 partially attenuated the clinical signs and restored basal histamine levels only in the abdominal aorta. "
5.	Amnesia (Dissociative Amnesia) 04/15/2007 - "In more pathophysiologically relevant pharmacodynamic models, GSK207040 (0.1, 0.3, 1 and 3mg/kg p.o.) and GSK334429 (0.3, 1 and 3mg/kg p.o.) significantly reversed amnesia induced by the cholinergic antagonist scopolamine in a passive avoidance paradigm. "

Related Drugs and Biologics

1.	6- ((3- cyclobutyl- 2,3,4,5- tetrahydro- 1H- 3- benzazepin- 7- yl)oxy)- N- methyl- 3- pyridinecarboxamide
2.	Niacinamide (Nicotinamide)
3.	Histamine H3 Antagonists
4.	Cholinergic Antagonists (Anticholinergics)
5.	Scopolamine (Hyoscine)
6.	Histamine (Histamine Dihydrochloride)
7.	Capsaicin (Zostrix)
8.	5- ((3- cyclobutyl- 2,3,4,5- tetrahydro- 1H- 3- benzazepin- 7- yl)oxy)- N- methyl- 2- pyrazinecarboxamide