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HPMA copolymer-Dox-AGM

an antineoplastic agent with aromotase inhibitory activity; structure in first source

Also Known As:

HPMA copolymer-AGM-Dox

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Duncan, Ruth: 1 article (01/2007)
2.	Gee, Julia: 1 article (01/2007)
3.	Gee, Siobhan: 1 article (01/2007)
4.	Greco, Francesca: 1 article (01/2007)
5.	Jones, Arwyn T: 1 article (01/2007)
6.	Nicholson, Robert I: 1 article (01/2007)
7.	Vicent, María J: 1 article (01/2007)

Related Diseases

1.

Breast Neoplasms (Breast Cancer)

01/22/2007 - "Investigating the mechanism of enhanced cytotoxicity of HPMA copolymer-Dox-AGM in breast cancer cells."
01/22/2007 - "To better understand the superior activity of HPMA copolymer-Dox-AGM, here experiments were undertaken using MCF-7 and MCF-7ca (aromatase-transfected) breast cancer cell lines to: further probe the synergistic cytotoxic effects of AGM and Dox in free and conjugated form; to compare the endocytic properties of HPMA copolymer-Dox-AGM and HPMA copolymer-Dox (binding, rate and mechanism of cellular uptake); the rate of drug liberation by lysosomal thiol-dependant proteases (i.e. "

Related Drugs and Biologics

1.	Sulfhydryl Compounds (Thiols)
2.	Peptide Hydrolases (Proteases)
3.	Aromatase (CYP19)
4.	hydroxypropyl methacrylate