CHIR-124

a potent inhibitor of Chk1 that potentiates the cytotoxicity of topoisomerase I poisons in vitro and in vivo; structure in first source

Also Known As:

((S)-3-(1H-benzo(d)imidazol-2-yl)-6-chloro-4-quinuclidin-3-ylamino)quinolin-2(1H)-one

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

1.	Tetraploidy 04/15/2009 - "Finally, Chir-124 could radiosensitize tetraploid cell lines, which were relatively resistant against DNA damaging agents. "
2.	Polyploidy 04/15/2009 - "In p53(-/-) cells, Chir-124 treatment induced a marked accumulation of polyploid cells that were characterized by micronucleation or multinucleation. "
3.	Photosensitivity Disorders (Photodermatitis) 12/01/2016 - "The latter suggested that the synergism between VE-821/2 or Chir-124 and UVA was not solely caused by specific blocking of ATR kinase but also ATR-independent photosensitization. "
4.	Neoplasms (Cancer) 01/15/2007 - "Finally, in an orthotopic breast cancer xenograft model, CHIR-124 potentiates the growth inhibitory effects of irinotecan by abrogating the G(2)-M checkpoint and increasing tumor apoptosis. "
5.	Breast Neoplasms (Breast Cancer) 01/15/2007 - "CHIR-124 abrogates the SN-38-induced S and G(2)-M checkpoints and potentiates apoptosis in MDA-MD-435 breast cancer cells. " 01/15/2007 - "Finally, in an orthotopic breast cancer xenograft model, CHIR-124 potentiates the growth inhibitory effects of irinotecan by abrogating the G(2)-M checkpoint and increasing tumor apoptosis. "

1.	Phosphotransferases (Kinase)
2.	DNA (Deoxyribonucleic Acid)
3.	Irinotecan (Camptosar)
4.	3- amino- 6- (4- (methylsulfonyl)phenyl)- N- phenylpyrazine- 2- carboxamide