sphaerophorin

a phytogenic antineoplastic agent isolated from various lichens; structure in first source

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

1.	Prostatic Neoplasms (Prostate Cancer) 11/01/2006 - "Our data show an induction of apoptotic death of advanced prostate cancer cells by sphaerophorin, pannarin and epiphorellic acid-1. " 11/01/2006 - "In the course of our continuing search for new natural anticancer compounds for treatment and/or prevention of prostate cancer, our laboratory has focused its search on poorly investigated lichen metabolites, sphaerophorin, pannarin and epiphorellic acid-1. "
2.	Necrosis 11/01/2006 - "Alternatively, we found a low, but significant (P<0.01) lactic dehydrogenase release at higher concentrations (50 micromol/l), suggesting that in these experimental conditions sphaerophorin, pannarin and epiphorellic acid-1 induce necrosis in DU-145 cells, through the increase in reactive oxygen species generation. "
3.	Melanoma (Melanoma, Malignant) 09/26/2008 - "The data obtained in cell culture show that these lichen metabolites inhibit the growth of melanoma cells, inducing an apoptotic cell death, demonstrated by the fragmentation of genomic DNA (COMET and TUNEL Assays) and by a significant increase of caspase-3 activity, and correlated, at least in part, to the increase of ROS generation, These results confirm the promising biological properties of sphaerophorin and pannarin and encourage further investigations on their molecular mechanisms."

1.	pannarin
2.	Caspase 3 (Caspase-3)
3.	Reactive Oxygen Species (Oxygen Radicals)
4.	Oxidoreductases (Dehydrogenase)
5.	DNA (Deoxyribonucleic Acid)
6.	epiphorellic acid-1