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stannous mesoporphyrin

Networked: 11 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Jadhav, Ashok: 3 articles (05/2013 - 01/2013)
2.	Ndisang, Joseph Fomusi: 3 articles (05/2013 - 01/2013)
3.	Tiwari, Shuchita: 3 articles (05/2013 - 01/2013)
4.	Rodriguez, Francisca: 2 articles (01/2022 - 12/2007)
5.	Abraham, Nader G: 2 articles (08/2013 - 01/2003)
6.	Lee, Paul: 2 articles (05/2013 - 01/2013)
7.	Mishra, Manish: 2 articles (01/2013 - 01/2013)
8.	Elmarakby, Ahmed A: 2 articles (01/2012 - 11/2010)
9.	Faulkner, Jessica: 2 articles (01/2012 - 11/2010)
10.	Sullivan, Jennifer C: 2 articles (01/2012 - 11/2010)

Related Diseases

1.	Inflammation (Inflammations) 01/01/2013 - "We investigated the effects of upregulating HO with hemin or inhibiting it with stannous-mesoporphyrin (SnMP) on hepatocyte ballooning injury, hepatic adiposity and inflammation in Zucker-diabetic-fatty rats (ZDFs), an obese type-2-diabetic model. " 01/01/2012 - "In vitro inhibition of HO with stannous mesoporphyrin (SnMP) increased glomerular NADPH oxidase activity and inflammation and blocked the anti-oxidant and anti-inflammatory effects of CoPP. "
2.	Hypertrophy 11/01/2013 - "We investigated the effects of the heme-oxygenase (HO) inducer hemin and the HO blocker stannous-mesoporphyrin (SnMP) on glucose metabolism, adipocyte hypertrophy and pro-inflammatory cytokines/mediators in Zucker diabetic fatty (ZDF) rats, a model characterized by obesity and type-2 diabetes. " 05/01/2013 - "In ZDFs, hemin administration increased HO activity; normalized glycemia; potentiated insulin signaling by enhancing insulin receptor substrate 1(IRS-1), phosphatidylinositol-3-kinase (PI3K), and protein kinase B (PKB)/Akt; suppressed pericardial adiposity, cardiac hypertrophy, and left ventricular longitudinal muscle fiber thickness, a pathophysiological feature of cardiomyocyte hypertrophy; and correspondingly reduced systolic blood pressure, total peripheral resistance, and pro-inflammatory/oxidative mediators, including nuclear factor κB (NF-κB), cJNK, c-Jun-N-terminal kinase (cJNK), endothelin (ET-1), tumor necrosis factor α (TNF-α), interleukin (IL)-6, IL-1β, activating protein 1 (AP-1), and 8-isoprostane, whereas the HO inhibitor, stannous mesoporphyrin, nullified the effects. "
3.	Acute Kidney Injury (Acute Renal Failure) 12/01/2007 - "These beneficial effects of CoCl(2) on ischemic acute renal failure seem to be due to HO-1 induction, because they were abolished by stannous mesoporphyrin, a HO inhibitor. "
4.	Proteinuria 11/01/2010 - "Inhibition of HO with stannous mesoporphyrin further increased blood pressure and proteinuria in SHR and blocked the ability of CoPP to reduce blood pressure and proteinuria in SHR. "
5.	Obesity 11/01/2013 - "We investigated the effects of the heme-oxygenase (HO) inducer hemin and the HO blocker stannous-mesoporphyrin (SnMP) on glucose metabolism, adipocyte hypertrophy and pro-inflammatory cytokines/mediators in Zucker diabetic fatty (ZDF) rats, a model characterized by obesity and type-2 diabetes. "

Related Drugs and Biologics

1.	Hemin (Panhematin)
2.	Heme Oxygenase (Decyclizing) (Heme Oxygenase)
3.	cobaltiprotoporphyrin
4.	Proto-Oncogene Proteins c-akt (Protein Kinase B)
5.	JNK Mitogen-Activated Protein Kinases
6.	NADPH Oxidases (NAD(P)H oxidase)
7.	Endothelins (Endothelin)
8.	Cytokines
9.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
10.	Insulin Receptor