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zapotin

isolated from zapote blanco; structure in first source

Also Known As:

5,6,2',6'-tetramethoxyflavone

Networked: 5 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Chromones: 159
        Flavonoids: 9773
        Flavones: 446
        zapotin: 5
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Chromones: 159
        Flavonoids: 9773
        Flavones: 446
        zapotin: 5

Experts

1.	Pezzuto, John M: 3 articles (11/2008 - 01/2007)
2.	Cuendet, Muriel: 2 articles (11/2008 - 01/2007)
3.	Cushman, Mark: 2 articles (11/2008 - 01/2007)
4.	Maiti, Arup: 2 articles (11/2008 - 01/2007)
5.	Chen, Yunlan: 1 article (06/2022)
6.	Han, Jiangqiong: 1 article (06/2022)
7.	Qian, Bin: 1 article (06/2022)
8.	Wang, Guoqin: 1 article (06/2022)
9.	Zhao, Hua: 1 article (06/2022)
10.	Budzianowski, Jaromir: 1 article (01/2016)

Related Diseases

1.	Aberrant Crypt Foci 01/01/2007 - "In the present study, we examined the effects of natural and synthetic zapotin in SW480, SW620, and HT-29 colon cancer cell lines and on the generation of aberrant crypt foci (ACF) using mice. "
2.	Colonic Neoplasms (Colon Cancer) 01/01/2007 - "The present study is the first to report the potent anticancer activity of zapotin and suggests a role for zapotin both as a chemopreventive and a chemotherapeutic agent against colon cancer." 01/01/2007 - "Zapotin treatment enhanced apoptosis in all of the colon cancer cell lines studied. " 01/01/2007 - "In the present study, we examined the effects of natural and synthetic zapotin in SW480, SW620, and HT-29 colon cancer cell lines and on the generation of aberrant crypt foci (ACF) using mice. "
3.	Carcinoma (Carcinomatosis) 06/09/2022 - "The current study aims to investigate the anticancer effects of zapotin flavone in human gastric carcinoma cells. " 06/09/2022 - "Anticancer effects of zapotin flavone in human gastric carcinoma cells are mediated via targeting m-TOR/PI3K/AKT signalling pathway."
4.	Body Weight (Weight, Body) 01/01/2007 - "For the study of ACF, 5-wk-old CF-1 mice were given subcutaneous injections of azoxymethane (AOM; 10 mg/kg body weight, BW) weekly for 2 wk, and zapotin (5 or 10 mg/kg BW; 46 or 92 pmol/kg BW) or vehicle was administered intragastrically 7 days/wk. The mean number of ACF for the control group was 14.0+/-2.3, whereas the mean numbers of ACF in the zapotin-treated groups were 6.2+/-1.7 and 4.6+/-1.4 at doses of 5.0 and 10.0 mg/kg BW, respectively. "
5.	Carcinogenesis 11/01/2008 - "Zapotin prevents mouse skin tumorigenesis during the stages of initiation and promotion." 11/01/2008 - "Zapotin, a flavonoid associated with Casimiroa edulis, was isolated as part of a program to discover natural inhibitors of carcinogenesis. " 01/01/2007 - "Zapotin, a phytochemical present in a Mexican fruit, prevents colon carcinogenesis." 11/01/2008 - "Topical zapotin significantly inhibited 7,12-dimethylbenz(a)anthracene/12-O-tetradecanoylphorbol-13-acetate-induced mouse skin tumorigenesis, using the anti-initiation and anti-promotion protocols. "

Related Drugs and Biologics

1.	Azoxymethane
2.	flavone
3.	Phytochemicals
4.	Flavonoids
5.	Acetates (Acetic Acid Esters)
6.	anthracene

Related Therapies and Procedures

1.	Subcutaneous Injections