subamolide B

cytotoxic constituent of the stems of Cinnamomum subavenium; structure in first source

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

1.	Squamous Cell Carcinoma (Epidermoid Carcinoma) 01/01/2013 - "Subamolide B Isolated from Medicinal Plant Cinnamomum subavenium Induces Cytotoxicity in Human Cutaneous Squamous Cell Carcinoma Cells through Mitochondrial and CHOP-Dependent Cell Death Pathways." 01/01/2013 - "Mechanistic studies on human cutaneous squamous cell carcinoma (SCC) cell line SCC12 highlighted the involvement of apoptosis in subamolide B-induced cytotoxicity, as evidenced by the activation of caspases-8, -9, -4, and -3, the increase in annexin V-positive population, and the partial restoration of cell viability by cotreatment with the pan-caspase inhibitor z-VAD-fmk. "
2.	Skin Neoplasms (Skin Cancer) 01/01/2013 - "We herein reported for the first time that subamolide B potently induced cytotoxicity against diverse human skin cancer cell lines while sparing nonmalignant cells. "

1.	Caspases
2.	Annexin A5
3.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone