13-desmethylspirolide C

from shellfish samples: mussels (Mytilus galloprovincialis), clams (Venerupis Pullastra) and razor clams (Ensis Arcuatus) obtained from different production areas in Galicia, Northwestern Spain; structure in first source

Also Known As:

Networked: 6 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Botana, Luis M: 4 articles (01/2018 - 08/2010)
2.	Vale, Carmen: 3 articles (01/2018 - 12/2011)
3.	Vieytes, Mercedes R: 3 articles (01/2018 - 08/2010)
4.	Alfonso, Amparo: 2 articles (03/2013 - 08/2010)
5.	Alonso, Eva: 2 articles (03/2013 - 12/2011)
6.	Giménez-Llort, Lydia: 2 articles (03/2013 - 12/2011)
7.	Otero, Paz: 2 articles (03/2013 - 08/2010)
8.	Bickmeyer, Ulf: 1 article (11/2020)
9.	Krock, Bernd: 1 article (11/2020)
10.	Nieva, Joyce A: 1 article (11/2020)

Related Diseases

1.	Alzheimer Disease (Alzheimer's Disease) 12/01/2011 - "In this study we examined the effect of 13-desmethyl spirolide-C (SPX) on amyloid-beta (Aβ) accumulation and tau hyperphosphorylation in a neuronal model from triple transgenic mice (3xTg) for Alzheimer disease (AD). " 03/01/2013 - "Benefit of 13-desmethyl spirolide C treatment in triple transgenic mouse model of Alzheimer disease: beta-amyloid and neuronal markers improvement." 01/01/2023 - "13-Desmethyl spirolide C is a marine natural product of the cyclic imine class that demonstrates remarkable bioactivity against several biomarkers of Alzheimer's Disease, which renders its [7,6]-spirocyclic imine pharmacophore of significant synthetic interest. " 01/01/2018 - "Previous work in our laboratory has demonstrated that after 4 days of treatment of primary mice cortical neurons with 13-desmethyl spirolide C, the compound ameliorated the glutamate induced toxicity and increased acetylcholine levels and the expression of the acetylcholine synthesizing enzyme being useful both in vitro and in vivo to decrease the brain pathology associated with Alzheimer's disease. "
2.	Shellfish Poisoning 08/01/2010 - "Analysis of the cultures demonstrated the existence of neurotoxins associated with paralytic shellfish poisoning toxins and two spirolides, 13-desmethyl spirolide C and 13,19-didesmethyl spirolide C. "
3.	Pheochromocytoma 11/27/2020 - "We investigated the effect of gymnodimine A (GYM A) and 13-desmethyl spirolide C (SPX 1) from Alexandrium ostenfeldii on rat pheochromocytoma (PC12) cells by monitoring intracellular calcium levels ([Ca]i). "

Related Drugs and Biologics

1.	Amyloid beta-Peptides
2.	Glutamic Acid (Glutamate)
3.	Biomarkers (Surrogate Marker)
4.	Neurotoxins
5.	Imines
6.	Enzymes
7.	Calcium
8.	Acetylcholine (Acetylcholine Chloride)
9.	gymnodimine A
10.	13,19-didesmethyl spirolide C