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fucosylated chondroitin sulfate

isolated from the sea cucumber Ludwigothurea grisea; structure in first source

Networked: 23 relevant articles (2 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Carbohydrates: 22023
- Polysaccharides: 15383
  - Glycosaminoglycans: 5640
    - Chondroitin: 773
      - Chondroitin Sulfates: 1594
        fucosylated chondroitin sulfate: 23

Experts

1.	Mourão, Paulo A S: 9 articles (05/2015 - 01/2004)
2.	Fonseca, Roberto J C: 5 articles (05/2015 - 12/2006)
3.	Hu, Shiwei: 3 articles (03/2019 - 11/2013)
4.	Wang, Jingfeng: 3 articles (03/2019 - 11/2013)
5.	Xue, Changhu: 3 articles (03/2019 - 11/2013)
6.	Pavão, Mauro S G: 3 articles (01/2014 - 05/2007)
7.	Li, Zhongjun: 2 articles (09/2018 - 01/2018)
8.	Liu, Huiying: 2 articles (09/2018 - 01/2018)
9.	Wu, Mingyi: 2 articles (09/2018 - 01/2018)
10.	Zhang, Xiao: 2 articles (09/2018 - 01/2018)

Related Diseases

1.	Insulin Resistance 07/01/2014 - "Fucosylated chondroitin sulfate from sea cucumber improves insulin sensitivity via activation of PI3K/PKB pathway." 07/01/2014 - "This study was to investigate the effects of fucosylated chondroitin sulfate (CHS) from sea cucumber on insulin sensitivity in skeletal muscle of type 2 diabetic mice induced by a high-fat high-sucrose diet (HFSD). " 09/15/2020 - "Sulfated fucan-dominated polysaccharide fraction from Thelenota ananas and fucosylated chondroitin sulfate-dominated polysaccharide fraction from Cucumaria frondosa ameliorated hyperglycemia, restored hypertriglyceridemia and hypercholesterolemia, decreased inflammatory status and oxidative stress, protected against liver injury, as well as improved insulin resistance and promoted accumulation of hepatic glycogen by activating IRS/PI3K/AKT signaling and regulating GSK-3β gene expression in T2DM rats. "
2.	Inflammation (Inflammations) 03/20/2019 - "This study evaluated the possible prebiotic effects of dietary fucosylated chondroitin sulfate from Acaudina molpadioides (Am-CHS) on the modulation of the gut microbiota and the improvement in the risk factors for chronic inflammation in high fat diet-fed mice. " 10/26/2022 - "Fucosylated Chondroitin Sulfate against Parkinson's Disease through Inhibiting Inflammation Induced by Gut Dysbiosis."
3.	Hyperglycemia 11/01/2013 - "In this study, we investigated the improvement of fucosylated chondroitin sulfate (CHS) from the cucumber Acaudina molpadioides on hyperglycemia in skeletal muscle of insulin resistant mice. " 11/01/2013 - "Fucosylated chondroitin sulfate from Acaudina molpadioides improves hyperglycemia via activation of PKB/GLUT4 signaling in skeletal muscle of insulin resistant mice." 09/15/2020 - "Sulfated fucan-dominated polysaccharide fraction from Thelenota ananas and fucosylated chondroitin sulfate-dominated polysaccharide fraction from Cucumaria frondosa ameliorated hyperglycemia, restored hypertriglyceridemia and hypercholesterolemia, decreased inflammatory status and oxidative stress, protected against liver injury, as well as improved insulin resistance and promoted accumulation of hepatic glycogen by activating IRS/PI3K/AKT signaling and regulating GSK-3β gene expression in T2DM rats. "
4.	Hypertriglyceridemia 09/15/2020 - "Sulfated fucan-dominated polysaccharide fraction from Thelenota ananas and fucosylated chondroitin sulfate-dominated polysaccharide fraction from Cucumaria frondosa ameliorated hyperglycemia, restored hypertriglyceridemia and hypercholesterolemia, decreased inflammatory status and oxidative stress, protected against liver injury, as well as improved insulin resistance and promoted accumulation of hepatic glycogen by activating IRS/PI3K/AKT signaling and regulating GSK-3β gene expression in T2DM rats. "
5.	Hypercholesterolemia 09/15/2020 - "Sulfated fucan-dominated polysaccharide fraction from Thelenota ananas and fucosylated chondroitin sulfate-dominated polysaccharide fraction from Cucumaria frondosa ameliorated hyperglycemia, restored hypertriglyceridemia and hypercholesterolemia, decreased inflammatory status and oxidative stress, protected against liver injury, as well as improved insulin resistance and promoted accumulation of hepatic glycogen by activating IRS/PI3K/AKT signaling and regulating GSK-3β gene expression in T2DM rats. "

Related Drugs and Biologics

1.	Prebiotics
2.	Polysaccharides (Glycans)
3.	Liver Glycogen
4.	Hypoglycemic Agents (Hypoglycemics)
5.	Sucrose (Saccharose)
6.	Insulin (Novolin)
7.	Anticoagulants
8.	Glycosaminoglycans
9.	L-Selectin
10.	P-Selectin

Related Therapies and Procedures

1.	Oral Administration