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5- (9- (4- cyanophenyl)- 3- (3,5- dichlorophenyl)- 1- methyl- 2,4- dioxo- 1,3,7- triazaspiro(4,4)non- 7- ylmethyl)- 3- thiophenecarboxylic acid

an LFA1 antagonist; structure in first source

Also Known As:

BMS 587101; BMS-587101; BMS587101

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Spiro Compounds: 2
      - 5-(9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro(4,4)non-7-ylmethyl)-3-thiophenecarboxylic acid: 1
- Sulfur Compounds: 278
  - Thiophenes: 257
    - 5-(9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro(4,4)non-7-ylmethyl)-3-thiophenecarboxylic acid: 1
Polycyclic Compounds: 6
- Spiro Compounds: 2
  - 5-(9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro(4,4)non-7-ylmethyl)-3-thiophenecarboxylic acid: 1
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Thiophenes: 257
    - 5-(9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro(4,4)non-7-ylmethyl)-3-thiophenecarboxylic acid: 1

Experts

1.	Barrish, Joel C: 1 article (04/2010)
2.	Davis, Patricia M: 1 article (04/2010)
3.	Dhar, T G Murali: 1 article (04/2010)
4.	Launay, Michele: 1 article (04/2010)
5.	McIntyre, Kim W: 1 article (04/2010)
6.	McKinnon, Murray: 1 article (04/2010)
7.	Potin, Dominique: 1 article (04/2010)
8.	Salter-Cid, Luisa: 1 article (04/2010)
9.	Shuster, David J: 1 article (04/2010)
10.	Skala, Stacey: 1 article (04/2010)

Related Diseases

1.	Inflammation (Inflammations) 04/01/2010 - "In paws taken from the collagen-induced arthritis study, the bones of vehicle-treated mice had extensive inflammation and bone destruction, whereas treatment with BMS-587101 resulted in marked protection. "
2.	Experimental Arthritis 04/01/2010 - "In paws taken from the collagen-induced arthritis study, the bones of vehicle-treated mice had extensive inflammation and bone destruction, whereas treatment with BMS-587101 resulted in marked protection. " 04/01/2010 - "Because BMS-587101 exhibits in vitro potency, cross-reactivity, and oral bioavailability in rodents, we evaluated the impact of oral administration of this compound in two different models of arthritis: Ab-induced arthritis and collagen-induced arthritis. "
3.	Arthritis (Polyarthritis) 04/01/2010 - "Because BMS-587101 exhibits in vitro potency, cross-reactivity, and oral bioavailability in rodents, we evaluated the impact of oral administration of this compound in two different models of arthritis: Ab-induced arthritis and collagen-induced arthritis. " 04/01/2010 - "In addition, BMS-587101 significantly reduced cytokine mRNA levels in the joints of Ab-induced arthritis animals as compared with those receiving vehicle alone. "

Related Drugs and Biologics

1.	Cytokines
2.	Messenger RNA (mRNA)

Related Therapies and Procedures

1.	Oral Administration