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4- (7- ((3- amino- 1- pyrrolidinyl)carbonyl)- 1- ethyl- 1H- imidazo(4,5- c)pyridin- 2- yl)- 1,2,5- oxadiazol- 3- amine

SB-772077-B is the (3S)-isomer; an NSAID with vasodilator activity that inhibits Rho kinases; structure in first source

Also Known As:

SB 772077-B; SB-772077-B

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Imidazoles: 150
      - 4-(7-((3-amino-1-pyrrolidinyl)carbonyl)-1-ethyl-1H-imidazo(4,5-c)pyridin-2-yl)-1,2,5-oxadiazol-3-amine: 2
    - Oxazoles: 89
      - Oxadiazoles: 146
        4-(7-((3-amino-1-pyrrolidinyl)carbonyl)-1-ethyl-1H-imidazo(4,5-c)pyridin-2-yl)-1,2,5-oxadiazol-3-amine: 2

Experts

1.	Badejo, Adeleke M: 1 article (07/2009)
2.	Casey, David B: 1 article (07/2009)
3.	Dhaliwal, Jasdeep S: 1 article (07/2009)
4.	Kadowitz, Philip J: 1 article (07/2009)
5.	Murthy, Subramanyam N: 1 article (07/2009)
6.	Bamford, Mark: 1 article (01/2007)
7.	Behm, David J: 1 article (01/2007)
8.	Bentley, Ross: 1 article (01/2007)
9.	Chen, Zunxuan: 1 article (01/2007)
10.	Doe, Chris: 1 article (01/2007)

Related Diseases

1.	Pulmonary Hypertension 07/01/2009 - "The intravenous injection of SB-772077-B decreased pulmonary and systemic arterial pressures in rats with monocrotaline-induced pulmonary hypertension. " 07/01/2009 - "The effects of SB-772077-B [4-(7-((3-amino-1-pyrrolidinyl)carbonyl)-1-ethyl-1H-imidazo(4,5-c)pyridin-2-yl)-1,2,5-oxadiazol-3-amine], an aminofurazan-based Rho kinase inhibitor, on the pulmonary vascular bed and on monocrotaline-induced pulmonary hypertension were investigated in the rat. "
2.	Chronic Disease (Chronic Diseases) 01/01/2007 - "SB-772077-B and GSK269962A represent a novel class of ROCK inhibitors that have profound effects in the vasculature and may enable us to further evaluate the potential beneficial effects of ROCK inhibition in animal models of cardiovascular as well as other chronic diseases."

Related Drugs and Biologics

1.	rho-Associated Kinases
2.	Monocrotaline
3.	Amines
4.	N- (3- ((2- (4- amino- 1,2,5- oxadiazol- 3- yl)- 1- ethyl- 1H- imidazo(4,5- c)pyridin- 6- yl)oxy)phenyl)- 4- ((2- (4- morpholinyl)ethyl)oxy)benzamide

Related Therapies and Procedures

1.	Intravenous Injections