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SD 1029

putative antineoplastic agent; structure in first source

Also Known As:

SD-1029; SD1029

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 3-Ring Heterocyclic Compounds
    - Xanthenes: 65
      - SD 1029: 4

Experts

1.	Duan, Zhenfeng: 2 articles (09/2009 - 11/2006)
2.	Kumlien, Eva: 1 article (07/2017)
3.	Larsson, David: 1 article (07/2017)
4.	Zelano, Johan: 1 article (07/2017)
5.	Åsberg, Signild: 1 article (07/2017)
6.	Asari, Yuko: 1 article (01/2017)
7.	Daimon, Makoto: 1 article (01/2017)
8.	Ishigame, Noriko: 1 article (01/2017)
9.	Kageyama, Kazunori: 1 article (01/2017)
10.	Nakada, Yuki: 1 article (01/2017)

Related Diseases

1.	Neoplasms (Cancer) 11/15/2006 - "These results show that SD-1029 directly abrogates the Jak-Stat3 signaling pathway in human cancer cells expressing constitutively active Stat, and add to the growing literature that validates this pathway as a viable target for further drug development. " 01/01/2017 - "In this study, we determined the effect of a potent and selective Jak2 inhibitor, SD1029, on ACTH production and proliferation in mouse AtT20 corticotroph tumor cells. "
2.	Stroke (Strokes) 07/01/2017 - "The mean latency between seizure and stroke was 1474days (SD 1029 days). "
3.	Ovarian Neoplasms (Ovarian Cancer) 11/15/2006 - "SD-1029 also enhances apoptosis induced by paclitaxel in ovarian cancer cells. " 11/15/2006 - "The antiapoptotic proteins Bcl-X(L) and survivin, target proteins of activated Stat3, are down-regulated by SD-1029 resulting in the induction of apoptosis in several human breast and ovarian cancer cell lines. "
4.	Chordoma 09/01/2009 - "Phosphorylation of Stat3 in chordoma cells in vitro and cellular proliferation in three-dimensional culture were inhibited by SD-1029. " 09/01/2009 - "MTT assay showed that the growth of all chordoma cell lines was inhibited by SD-1029. " 09/01/2009 - "Three chordoma cell lines were exposed to SD-1029, a novel inhibitor of Stat3 activation. " 09/01/2009 - "The expression of Stat3 signaling cascade was inhibited in all chordoma cell lines after treatment with SD-1029. "

Related Drugs and Biologics

1.	Adrenocorticotropic Hormone (ACTH)
2.	Paclitaxel (Taxol)
3.	Proteins (Proteins, Gene)
4.	Survivin

Related Therapies and Procedures

1.	Aftercare (After-Treatment)