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haplamine

isolated from Haplophyllum acutifolium; structure in first source

Networked: 1 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - haplamine: 1
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinolines: 146
      - Quinolones: 2938
        haplamine: 1

Experts

1.	Akhmedjanova, Valentina: 1 article (08/2008)
2.	Aubert, Claude: 1 article (08/2008)
3.	Ciccolini, Joseph: 1 article (08/2008)
4.	Ea, Sompheary: 1 article (08/2008)
5.	Giacometti, Sarah: 1 article (08/2008)

Related Diseases

1.	Neoplasms (Cancer) 08/01/2008 - "The efficacy of haplamine was compared with those of the respective reference drugs for treating digestive cancers (e. " 08/01/2008 - "Cytotoxic effects of haplamine and its major metabolites on human cancer cell lines." 08/01/2008 - "Interestingly, we found that haplamine showed significant antiproliferative efficacy on resistant SW620 colorectal cells, whereas the reference drug 5-FU was ineffective (32 vs. 73 microM, p < 0.01 t- test), thus suggesting that haplamine could be of interest for treating digestive cancers resistant to standard fluoropyrimidines. "
2.	Colorectal Neoplasms (Colorectal Cancer) 08/01/2008 - "The purpose of the present study was to investigate in vitro the cytotoxic properties of haplamine and its major metabolites (trans/cis-3,4-dihydroxyhaplamine) on human pancreatic cancer, colorectal cancer and hepatic cancer cell lines. " 08/01/2008 - "The IC50 values of of haplamine were 52.5 +/- 2.6, 24.3 +/- 0.7; 41.5 +/- 2.5, 72 +/- 2, 32 +/- 2.2 and 59.7 +/- 2.1 microM in human pancreatic cancer (Capan1 and Capan2), colorectal cancer (LS174T, HT29, and SW620) and hepatic cancer (HepG2) cells, respectively. "
3.	Pancreatic Neoplasms (Pancreatic Cancer) 08/01/2008 - "Similarly, haplamine proved to be significantly more potent in pancreatic cells than gemcitabine, the reference cytotoxic drug for treating pancreatic carcinomas. " 08/01/2008 - "The purpose of the present study was to investigate in vitro the cytotoxic properties of haplamine and its major metabolites (trans/cis-3,4-dihydroxyhaplamine) on human pancreatic cancer, colorectal cancer and hepatic cancer cell lines. " 08/01/2008 - "The IC50 values of of haplamine were 52.5 +/- 2.6, 24.3 +/- 0.7; 41.5 +/- 2.5, 72 +/- 2, 32 +/- 2.2 and 59.7 +/- 2.1 microM in human pancreatic cancer (Capan1 and Capan2), colorectal cancer (LS174T, HT29, and SW620) and hepatic cancer (HepG2) cells, respectively. "
4.	Liver Neoplasms (Liver Cancer) 08/01/2008 - "The purpose of the present study was to investigate in vitro the cytotoxic properties of haplamine and its major metabolites (trans/cis-3,4-dihydroxyhaplamine) on human pancreatic cancer, colorectal cancer and hepatic cancer cell lines. " 08/01/2008 - "The IC50 values of of haplamine were 52.5 +/- 2.6, 24.3 +/- 0.7; 41.5 +/- 2.5, 72 +/- 2, 32 +/- 2.2 and 59.7 +/- 2.1 microM in human pancreatic cancer (Capan1 and Capan2), colorectal cancer (LS174T, HT29, and SW620) and hepatic cancer (HepG2) cells, respectively. "
5.	Testicular Neoplasms (Testicular Cancer) 08/01/2008 - "Haplamine, extracted from Haplophyllum perforatum, is widely used in Central Asia for treating various diseases, including testicular cancer. "

Related Drugs and Biologics

1.	Fluorouracil (Carac)
2.	Gemcitabine