(N-(1-(((cyanoimino)(5-quinolinylamino) methyl) amino)- 2,2- dimethylpropyl)- 2- (3,4- dimethoxyphenyl)acetamide)

Also Known As:

A-740003; A740003

Networked: 26 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amides: 2428
  - Acetamides: 21
    - (N-(1-(((cyanoimino)(5-quinolinylamino) methyl) amino)-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide): 26
- Carboxylic Acids: 973
  - Acyclic Acids
    - Acetates: 4994
      - Acetamides: 21
        (N-(1-(((cyanoimino)(5-quinolinylamino) methyl) amino)-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide): 26
Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinolines: 146
      - (N-(1-(((cyanoimino)(5-quinolinylamino) methyl) amino)-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide): 26

Experts

1.	Coutinho-Silva, Robson: 2 articles (04/2022 - 01/2014)
2.	Xiao, Zhi: 2 articles (01/2022 - 01/2018)
3.	Adinolfi, Elena: 2 articles (12/2021 - 01/2019)
4.	De Marchi, Elena: 2 articles (12/2021 - 01/2019)
5.	Di Virgilio, Francesco: 2 articles (12/2021 - 01/2019)
6.	Alfieri, Ottavio: 2 articles (03/2019 - 01/2017)
7.	Baccellieri, Domenico: 2 articles (03/2019 - 01/2017)
8.	Castellano, Renata: 2 articles (03/2019 - 01/2017)
9.	Chiesa, Roberto: 2 articles (03/2019 - 01/2017)
10.	Ferrara, David: 2 articles (03/2019 - 01/2017)

Related Diseases

1.	Hypoxia (Hypoxemia) 03/01/2021 - "The pathological changes of lung tissue induced by hypoxia were significantly relieved by treatment with a P2X7R antagonist, A740003. " 03/01/2019 - "Migrating cells expressed HIF1α-regulated canopy FGF-signalling regulator 2 and CD117, and led to primary cells with SMC-like phenotype (VSMC), P2X7+. We investigated in VSMC the effects of hypoxia, of treatment with tumour necrosis factor-α (TNFα) and/or with P2X7 antagonist, A740003. "
2.	Atherosclerosis 01/01/2017 - "These data firstly demonstrated A740003 suitability as a specific tool to decrease inflammatory status in human vessels and might support the design of studies applying P2X7 antagonists for the local targeting and tailored therapy of atherosclerosis."
3.	Sepsis (Septicemia) 01/01/2017 - "In this study, mice were treated with the P2X7R antagonist A740003 or the agonist BzATP by intra-peritoneal injection after the induction of gut-origin sepsis. "
4.	Seizures (Absence Seizure) 11/15/2023 - "However, A740003 in conjunction with LZP delayed the onset of seizures. " 11/15/2023 - "This study evaluated the effect of the selective P2X7R antagonist A740003 on acute seizures in the dentate gyrus (DG) of hippocampal brain slices, where P2X7Rs are highly expressed, with a view to establishing the potential of P2X7R antagonists as a therapy or adjunct with lorazepam (LZP) in refractory SE. "
5.	Pain (Aches) 01/01/2022 - "As noted, A740003 did not prevent the behavioral changes in the AA-induced pain model. " 01/01/2022 - "The A-740003 can relieve pain and reduce the inflammation progression in rats with AP." 11/20/2023 - "Moreover, PPVI decreased expression of IL-6 and IL-8 was observed in the serum of the inflammatory pain mice model and reduced phosphorylation of p38 and ERK1/2 in the dorsal root ganglia while the reductions of expression of IL-6 and phosphorylation of ERK1/2 were not observed after the pre-treatment with A740003 (an antagonist of the P2X7R). " 01/01/2018 - "The intra-vlPAG injection of A-740003 pretreatment partly but significantly antagonized the analgesic effect of tramadol on bone cancer pain rats. "

Related Drugs and Biologics

1.	Lorazepam (Ativan)
2.	3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate
3.	Purinergic P2X7 Receptors
4.	Carrageenan
5.	Coloring Agents (Dyes)
6.	Analgesics (Analgesic Drugs)
7.	Adenosine Triphosphate (ATP)
8.	Inflammasomes
9.	Interleukin-8 (Interleukin 8)
10.	Cytokines

Related Therapies and Procedures

1.	Therapeutics